Gabrielle Fredman
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Explore the profile of Gabrielle Fredman including associated specialties, affiliations and a list of published articles.
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65
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4012
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Recent Articles
11.
Lipscomb M, Walis S, Marinello M, Mena H, Spite M, Fredman G
bioRxiv
. 2023 Apr;
PMID: 37066358
Introduction/objective: Dysregulated inflammation-resolution programs are associated with atherosclerosis progression. Inflammation-resolution is in part mediated by Resolvins, including Resolvin D2 (RvD2). RvD2, which activates a G-protein coupled receptor (GPCR) called GPR18,...
12.
Grazda R, Seyfried A, Maddipatti K, Fredman G, MacNamara K
bioRxiv
. 2023 Mar;
PMID: 36909559
Current treatments for severe aplastic anemia (SAA) rely on hematopoietic stem cell (HSC) transplantation and immunosuppressive therapies, however these treatments are not always effective. While immune-mediated destruction and inflammation are...
13.
Fitzgerald H, Bonin J, Sadhu S, Lipscomb M, Biswas N, Decker C, et al.
bioRxiv
. 2023 Jan;
PMID: 36711905
Aging is associated with non-resolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a pro-resolving ligand that acts through the G-protein coupled receptor (GPCR) called GRP18. Using an unbiased screen,...
14.
Howard J, Smith J, Fredman G, MacNamara K
Stem Cell Reports
. 2021 Nov;
16(12):2887-2899.
PMID: 34798063
Severe infection can dramatically alter blood production, but the mechanisms driving hematopoietic stem and progenitor cell (HSC/HSPC) loss have not been clearly defined. Using Ixodes ovatus Ehrlichia (IOE), a tick-borne...
15.
Fredman G, MacNamara K
Cardiovasc Res
. 2021 Oct;
117(13):2563-2574.
PMID: 34609505
The resolution of inflammation (or inflammation-resolution) is an active and highly coordinated process. Inflammation-resolution is governed by several endogenous factors, and specialized pro-resolving mediators (SPMs) are one such class of...
16.
Zhang H, Chen Z, Fredman G, Gomez D, Grumbach I, Huang N, et al.
Arterioscler Thromb Vasc Biol
. 2021 Sep;
41(11):2641-2647.
PMID: 34547925
[Figure: see text].
17.
Sadhu S, Decker C, Sansbury B, Marinello M, Seyfried A, Howard J, et al.
J Immunol
. 2021 Aug;
207(7):1812-1823.
PMID: 34462312
Radiation is associated with tissue damage and increased risk of atherosclerosis, but there are currently no treatments and a very limited mechanistic understanding of how radiation impacts tissue repair mechanisms....
18.
Decker C, Sadhu S, Fredman G
Front Immunol
. 2021 Jun;
12:660865.
PMID: 34177900
The resolution of inflammation is a tissue protective program that is governed by several factors including specialized pro-resolving mediators (SPMs), proteins, gasses and nucleotides. Pro-resolving mediators activate counterregulatory programs to...
19.
Martino N, Ramos R, Lu S, Leyden K, Tomaszek L, Sadhu S, et al.
JCI Insight
. 2021 Jun;
6(14).
PMID: 34138760
SOCS3 is the main inhibitor of the JAK/STAT3 pathway. This pathway is activated by interleukin 6 (IL-6), a major mediator of the cytokine storm during shock. To determine its role...
20.
Kasikara C, Schilperoort M, Gerlach B, Xue C, Wang X, Zheng Z, et al.
J Clin Invest
. 2021 Feb;
131(8).
PMID: 33630758
Efferocytosis, the process through which apoptotic cells (ACs) are cleared through actin-mediated engulfment by macrophages, prevents secondary necrosis, suppresses inflammation, and promotes resolution. Impaired efferocytosis drives the formation of clinically...