Ira Tabas
Overview
Explore the profile of Ira Tabas including associated specialties, affiliations and a list of published articles.
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198
Citations
23405
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Recent Articles
1.
Liu W, Hardaway B, Kim E, Pauli J, Wettich J, Yalcinkaya M, et al.
J Clin Invest
. 2024 Nov;
135(1).
PMID: 39531316
Clonal hematopoiesis (CH) increases inflammasome-linked atherosclerosis, but the mechanisms by which CH mutant cells transmit inflammatory signals to nonmutant cells are largely unknown. To address this question, we transplanted 1.5%...
2.
Sukka S, Ampomah P, Darville L, Ngai D, Wang X, Kuriakose G, et al.
Nat Metab
. 2024 Sep;
6(11):2204.
PMID: 39285251
No abstract available.
3.
Sukka S, Ampomah P, Darville L, Ngai D, Wang X, Kuriakose G, et al.
Nat Metab
. 2024 Sep;
6(9):1736-1755.
PMID: 39242914
Macrophage efferocytosis prevents apoptotic cell (AC) accumulation and triggers inflammation-resolution pathways. The mechanisms linking efferocytosis to resolution often involve changes in macrophage metabolism, but many gaps remain in our understanding...
4.
Wu X, Wang Z, Croce K, Li F, Cui J, DAgati V, et al.
bioRxiv
. 2024 Sep;
PMID: 39229152
Efficient efferocytosis is essential for maintaining homeostasis. Excessive apoptotic cell (AC) death and impaired macrophage efferocytosis lead to autoantigen release and autoantibody production, immune activation, and organ damage. It remains...
5.
Ngai D, Sukka S, Tabas I
Front Immunol
. 2024 Jun;
15:1403150.
PMID: 38873597
The interplay between myeloid cells and T-lymphocytes is critical to the regulation of host defense and inflammation resolution. Dysregulation of this interaction can contribute to the development of chronic inflammatory...
6.
Moore M, Wang X, Kennelly J, Shi H, Ishino Y, Kano K, et al.
Hepatology
. 2024 May;
81(2):576-590.
PMID: 38776184
Background And Aims: The common genetic variant rs641738 C>T is a risk factor for metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis (MASH), including liver fibrosis, and is associated...
7.
Shi H, Moore M, Wang X, Tabas I
JHEP Rep
. 2024 Jan;
6(1):100960.
PMID: 38234410
The process of dead cell clearance by phagocytic cells, called efferocytosis, prevents inflammatory cell necrosis and promotes resolution and repair. Defective efferocytosis contributes to the progression of numerous diseases in...
8.
Wang X, Moore M, Shi H, Miyata Y, Donnelly S, Radiloff D, et al.
Mol Ther Methods Clin Dev
. 2023 Dec;
31:101165.
PMID: 38144682
Nonalcoholic steatohepatitis (NASH) is emerging as the most common cause of liver disease. Although many studies in mouse NASH models have suggested therapies, translation to humans is poor, with no...
9.
Ngai D, Schilperoort M, Tabas I
Nat Metab
. 2023 Nov;
5(12):2206-2219.
PMID: 38012414
The clearance of apoptotic cells by macrophages (efferocytosis) prevents necrosis and inflammation and activates pro-resolving pathways, including continual efferocytosis. A key resolution process in vivo is efferocytosis-induced macrophage proliferation (EIMP),...
10.
Yalcinkaya M, Liu W, Thomas L, Olszewska M, Xiao T, Abramowicz S, et al.
Circulation
. 2023 Oct;
148(22):1764-1777.
PMID: 37781816
Background: Clonal hematopoiesis (CH) has emerged as an independent risk factor for atherosclerotic cardiovascular disease, with activation of macrophage inflammasomes as a potential underlying mechanism. The NLRP3 (NLR family pyrin...