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Katherine C MacNamara

Explore the profile of Katherine C MacNamara including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Bonin J, Torres S, Marcinkiewicz A, Duhamel G, Yang X, Pal U, et al.
Front Immunol . 2024 Sep; 15:1430419. PMID: 39229265
Tick-borne infections are increasing in the United States and around the world. The most common tick-borne disease in the United States is Lyme disease caused by infection with the spirochete...
2.
Grazda R, Seyfried A, Maddipati K, Fredman G, MacNamara K
Cell Death Dis . 2024 May; 15(5):324. PMID: 38724533
Severe aplastic anemia (SAA) is a rare, fatal disease characterized by severe cytopenias and loss of hematopoietic stem cells (HSCs). Immune-mediated destruction and inflammation are known drivers of SAA, however,...
3.
Biswas N, Bahr A, Howard J, Bonin J, Grazda R, MacNamara K
Stem Cell Reports . 2024 Apr; 19(5):639-653. PMID: 38608679
Sepsis survivors exhibit immune dysfunction, hematological changes, and increased risk of infection. The long-term impacts of sepsis on hematopoiesis were analyzed using a surgical model of murine sepsis, resulting in...
4.
Lipscomb M, Walis S, Marinello M, Mena H, MacNamara K, Spite M, et al.
FASEB J . 2024 Mar; 38(6):e23555. PMID: 38498346
Dysregulated inflammation-resolution programs are associated with atherosclerosis progression. Resolvins, in part, mediate inflammation-resolution programs. Indeed, Resolvin D2 (RvD2) activates GPR18, a G-protein-coupled receptor, and limits plaque progression, though the cellular...
5.
Kinguyu D, Nti-Kyemereh L, Bonin J, Feustel P, Tram M, MacNamara K, et al.
J Neuroimmunol . 2023 Sep; 384:578204. PMID: 37774553
Opioids have long been used for clinical pain management, but also have addictive properties that have contributed to the ongoing opioid epidemic. While opioid activation of opioid receptors is well...
6.
Fitzgerald H, Bonin J, Khan S, Eid M, Sadhu S, Rahtes A, et al.
Am J Pathol . 2023 Sep; 193(12):1953-1968. PMID: 37717941
Aging is associated with nonresolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a proresolving ligand that acts through the G-protein-coupled receptor called GPR18. Unbiased RNA sequencing revealed increased Gpr18...
7.
Grazda R, Seyfried A, Maddipatti K, Fredman G, MacNamara K
bioRxiv . 2023 Mar; PMID: 36909559
Current treatments for severe aplastic anemia (SAA) rely on hematopoietic stem cell (HSC) transplantation and immunosuppressive therapies, however these treatments are not always effective. While immune-mediated destruction and inflammation are...
8.
Fitzgerald H, Bonin J, Sadhu S, Lipscomb M, Biswas N, Decker C, et al.
bioRxiv . 2023 Jan; PMID: 36711905
Aging is associated with non-resolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a pro-resolving ligand that acts through the G-protein coupled receptor (GPCR) called GRP18. Using an unbiased screen,...
9.
MacNamara K, Nolte M
Cells . 2022 May; 11(9). PMID: 35563892
This Special Issue entitled "The Impact of Immune Activation on Hematopoiesis" aims to bring together review and primary articles focused on distinct types of immune activation that impact hematopoiesis [...].
10.
Goedhart M, Slot E, Pascutti M, Geerman S, Rademakers T, Nota B, et al.
Cells . 2022 Jan; 11(1). PMID: 35011617
Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC). When analyzing...