Gabriella La Spada
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Explore the profile of Gabriella La Spada including associated specialties, affiliations and a list of published articles.
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9
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13
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Recent Articles
1.
Rullo M, La Spada G, Stefanachi A, Macchia E, Pisani L, Leonetti F
Molecules
. 2025 Feb;
30(4).
PMID: 40005200
Alzheimer's disease (AD) causes a great socioeconomic burden because of its increasing prevalence and the lack of effective therapies. The multifactorial nature of AD prompts researchers to search for new...
2.
Sblano S, Boccarelli A, Deruvo C, La Spada G, De Candia M, Purgatorio R, et al.
Eur J Med Chem
. 2024 Dec;
283():117159.
PMID: 39700873
Drug resistance in cancer is determined by genetic mutations and adaptations of tumor cells to drug treatments, raising a challenge in the treatment of cancer. Factors such as prolonged drug...
3.
Francavilla F, Intranuovo F, La Spada G, Lacivita E, Catto M, Graps E, et al.
ChemMedChem
. 2024 Dec;
:e202400672.
PMID: 39651728
Aging naturally involves a decline in biological functions, often triggering a disequilibrium of physiological processes. A common outcome is the altered response exerted by the immune system to counteract infections,...
4.
Leuci R, Simic S, Carrieri A, Chaves S, La Spada G, Brunetti L, et al.
Bioorg Chem
. 2024 Oct;
153:107895.
PMID: 39454499
In recent years, an increasing amount of work has been carried out regarding the study of the etiopathology of Alzheimer's Disease (AD). This neurodegenerative disease is characterized by several organic...
5.
Eddahmi M, La Spada G, Domingo L, Vergoten G, Bailly C, Catto M, et al.
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928509
Inhibitors of monoamine oxidases (MAOs) are of interest for the treatment of neurodegenerative disorders and other human pathologies. In this frame, the present work describes different synthetic strategies to obtain...
6.
La Spada G, Miniero D, Rullo M, Cipolloni M, Delre P, Colliva C, et al.
Eur J Med Chem
. 2024 May;
274:116511.
PMID: 38820854
A structure-based drug design approach was focused on incorporating phenyl ring heterocyclic bioisosteres into coumarin derivative 1, previously reported as potent dual AChE-MAO B inhibitor, with the aim of improving...
7.
Rullo M, La Spada G, Miniero D, Gottinger A, Catto M, Delre P, et al.
Eur J Med Chem
. 2023 May;
255:115352.
PMID: 37178666
Following a hybridization strategy, a series of 5-substituted-1H-indazoles were designed and evaluated in vitro as inhibitors of human monoamine oxidase (hMAO) A and B. Among structural modifications, the bioisostere-based introduction...
8.
Kulikova L, Raesi G, Levickaya D, Purgatorio R, La Spada G, Catto M, et al.
Molecules
. 2023 Feb;
28(4).
PMID: 36838649
In this work, 2-alkyl-10-chloro-1,2,3,4-tetrahydrobenzo[][1,6]naphthyridines were obtained and their reactivity was studied. Novel derivatives of the tricyclic scaffold, including 1-phenylethynyl (), 1-indol-3-yl (), and azocino[4,5-]quinoline () derivatives, were synthesized and characterized...
9.
Hafez D, Dubiel M, La Spada G, Catto M, Reiner-Link D, Syu Y, et al.
J Enzyme Inhib Med Chem
. 2023 Feb;
38(1):2175821.
PMID: 36789662
Neurodegenerative diseases such as Alzheimer's disease (AD) are multifactorial with several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed ligands (MTDLs) which interact with different biological targets relevant to...
10.
Eddahmi M, La Spada G, Hafid A, Khouili M, Catto M, Bouissane L
Bioorg Chem
. 2022 Nov;
130:106261.
PMID: 36399866
In this work, we have investigated the one pot strategy for the Cu(I)-mediated synthesis of new triazoles bearing nitroindazole moieties using different copper catalysts. The biological activity of newly synthesized...