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» Authors » Mariagrazia Rullo

Mariagrazia Rullo

Explore the profile of Mariagrazia Rullo including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 15
Citations 94
Followers 0
Related Specialties
Chemistry
Biology
Pharmacology
Top 10 Co-Authors
Leonardo Pisani
Marco Catto
Modesto De Candia
Cosimo Damiano Altomare
Antonio Carrieri
Cosimo D Altomare
Daniela Valeria Miniero
Saverio Cellamare
Francesco Leonetti
Grazia Maria Liuzzi
Published In
Eur J Med Chem
Molecules
J Sep Sci
ChemMedChem
Viruses
Affiliations
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Recent Articles
1.
Playing Around the Coumarin Core in the Discovery of Multimodal Compounds Directed at Alzheimer's-Related Targets: A Recent Literature Overview
Rullo M, La Spada G, Stefanachi A, Macchia E, Pisani L, Leonetti F
Molecules . 2025 Feb; 30(4). PMID: 40005200
Alzheimer's disease (AD) causes a great socioeconomic burden because of its increasing prevalence and the lack of effective therapies. The multifactorial nature of AD prompts researchers to search for new...
2.
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization
La Spada G, Miniero D, Rullo M, Cipolloni M, Delre P, Colliva C, et al.
Eur J Med Chem . 2024 May; 274:116511. PMID: 38820854
A structure-based drug design approach was focused on incorporating phenyl ring heterocyclic bioisosteres into coumarin derivative 1, previously reported as potent dual AChE-MAO B inhibitor, with the aim of improving...
3.
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
Al-Saad O, Gabr M, Darwish S, Rullo M, Pisani L, Miniero D, et al.
Eur J Med Chem . 2024 Mar; 269:116266. PMID: 38490063
In neurodegenerative diseases, using a single molecule that can exert multiple effects to modify the disease may have superior activity over the classical "one molecule-one target" approach. Herein, we describe...
4.
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors
Rullo M, La Spada G, Miniero D, Gottinger A, Catto M, Delre P, et al.
Eur J Med Chem . 2023 May; 255:115352. PMID: 37178666
Following a hybridization strategy, a series of 5-substituted-1H-indazoles were designed and evaluated in vitro as inhibitors of human monoamine oxidase (hMAO) A and B. Among structural modifications, the bioisostere-based introduction...
5.
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules
Pisani L, Catto M, Muncipinto G, Nicolotti O, Carrieri A, Rullo M, et al.
Front Chem . 2022 Oct; 10:1002547. PMID: 36300022
The coumarin core (i.e., 1-benzopyran-2 (2)-one) is a structural motif highly recurrent in both natural products and bioactive molecules. Indeed, depending on the substituents and branching positions around the byciclic...
6.
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology
Pisani L, De Candia M, Rullo M, Altomare C
Methods Mol Biol . 2022 Sep; 2558:207-220. PMID: 36169866
Hansch-type regression analysis enables the derivation of quantitative structure-activity relationship (QSAR) equations correlating bioactivity data with physicochemical parameters accounting for hydrophobicity, electronic properties, and steric effects of molecules or functional...
7.
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection
De Maio F, Rullo M, De Candia M, Purgatorio R, Lopopolo G, Santarelli G, et al.
Viruses . 2022 Aug; 14(8). PMID: 36016352
Coagulation factor Xa (fXa) and thrombin (thr) are widely expressed in pulmonary tissues, where they may catalyze, together with the transmembrane serine protease 2 (TMPRSS2), the coronaviruses spike protein (SP)...
8.
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors
Paolino M, Rullo M, Maramai S, De Candia M, Pisani L, Catto M, et al.
RSC Med Chem . 2022 Aug; 13(7):873-883. PMID: 35923722
Neurodegenerative diseases are multifactorial disorders characterized by protein misfolding, oxidative stress, and neuroinflammation, finally resulting in neuronal loss and cognitive dysfunctions. Nowadays, an attractive strategy to improve the classical treatments...
9.
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies
Rullo M, Cipolloni M, Catto M, Colliva C, Miniero D, Latronico T, et al.
J Med Chem . 2022 Feb; 65(5):3962-3977. PMID: 35195417
Bioisosteric H/F or CHOH/CFH replacement was introduced in coumarin derivatives previously characterized as dual AChE-MAO B inhibitors to probe the effects on both inhibitory potency and drug-likeness. Along with in...
10.
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease
Purgatorio R, Gambacorta N, De Candia M, Catto M, Rullo M, Pisani L, et al.
Molecules . 2021 Sep; 26(17). PMID: 34500640
Recently, the direct thrombin (thr) inhibitor dabigatran has proven to be beneficial in animal models of Alzheimer's disease (AD). Aiming at discovering novel multimodal agents addressing thr and AD-related targets,...