Gabriel N Maine
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Explore the profile of Gabriel N Maine including associated specialties, affiliations and a list of published articles.
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22
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Recent Articles
11.
Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine G, et al.
J Clin Invest
. 2013 Apr;
123(5):2244-56.
PMID: 23563313
NF-κB is a master regulator of inflammation and has been implicated in the pathogenesis of immune disorders and cancer. Its regulation involves a variety of steps, including the controlled degradation...
12.
Zimmerman M, Kumar V, Maine G, Sykes E
Clin Chim Acta
. 2011 Oct;
413(1-2):344-5.
PMID: 21963463
No abstract available.
13.
Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine G, et al.
J Biol Chem
. 2011 Jul;
286(37):32355-65.
PMID: 21778237
Cullin RING ligases (CRLs), the most prolific class of ubiquitin ligase enzymes, are multimeric complexes that regulate a wide range of cellular processes. CRL activity is regulated by CAND1 (Cullin-associated...
14.
Maine G, Li H, Zaidi I, Basrur V, Elenitoba-Johnson K, Burstein E
Nat Protoc
. 2010 Jul;
5(8):1447-59.
PMID: 20671728
Ubiquitination can have profound effects on the stability and function of cellular proteins. Mass spectrometry (MS) can be used to map the specific amino acid residues that are conjugated to...
15.
Maine G, Gluck N, Zaidi I, Burstein E
Cold Spring Harb Protoc
. 2010 Feb;
2009(11):pdb.prot5318.
PMID: 20150057
The tandem affinity purification (TAP) procedure was pioneered in yeast for the purpose of purifying and characterizing protein complexes. While affinity purification is relatively easy to perform, nonspecific protein interactions...
16.
Mao X, Gluck N, Li D, Maine G, Li H, Zaidi I, et al.
Genes Dev
. 2009 Apr;
23(7):849-61.
PMID: 19339690
The transcription factor NF-kappaB is a critical regulator of inflammatory and cell survival signals. Proteasomal degradation of NF-kappaB subunits plays an important role in the termination of NF-kappaB activity, and...
17.
Muller P, van de Sluis B, Groot A, Verbeek D, Vonk W, Maine G, et al.
Traffic
. 2009 Feb;
10(5):514-27.
PMID: 19220812
Copper metabolism MURR1 domain1 (COMMD1) is a novel inhibitor of the transcription factors NF-kappaB and HIF-1, which play important roles in inflammation and tumor growth, respectively. In this study, we...
18.
Maine G, Mao X, Muller P, Komarck C, Klomp L, Burstein E
Biochem J
. 2008 Sep;
417(2):601-9.
PMID: 18795889
COMMD {COMM [copper metabolism Murr1 (mouse U2af1-rs1 region 1)] domain-containing} proteins participate in several cellular processes, ranging from NF-kappaB (nuclear factor kappaB) regulation, copper homoeostasis, sodium transport and adaptation to...
19.
Maine G, Burstein E
Cell Cycle
. 2007 Mar;
6(6):672-6.
PMID: 17361106
The COMM domain containing (COMMD) family of proteins represents a recently discovered set of evolutionarily conserved factors characterized by the presence of a defining carboxy-terminal motif. In vertebrates, there are...
20.
Maine G, Mao X, Komarck C, Burstein E
EMBO J
. 2006 Dec;
26(2):436-47.
PMID: 17183367
NF-kappaB is a pleiotropic transcription factor involved in multiple processes, including inflammation and oncogenesis. We have previously reported that COMMD1 represses kappaB-dependent transcription by negatively regulating NF-kappaB-chromatin interactions. Recently, ubiquitination...