G J Kaczorowski
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Explore the profile of G J Kaczorowski including associated specialties, affiliations and a list of published articles.
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99
Citations
2581
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Recent Articles
1.
Kaczorowski G, Garcia M
Int Rev Neurobiol
. 2016 May;
128:439-75.
PMID: 27238271
High conductance, calcium-activated potassium (BK) channels (KCa1.1) are important in regulating physiologic responses in many types of tissues and, as such, present opportunities for development of new therapeutic agents. Both...
2.
McMillan L, Carr R, Young C, Astin J, Lowe R, Parker E, et al.
Mol Genet Genomics
. 2003 Jul;
270(1):9-23.
PMID: 12884010
The gene cluster required for paxilline biosynthesis in Penicillium paxilli contains two cytochrome P450 monooxygenase genes, paxP and paxQ. The primary sequences of both proteins are very similar to those...
3.
Hanner M, Green B, Gao Y, Schmalhofer W, Matyskiela M, Durand D, et al.
Biochemistry
. 2001 Sep;
40(39):11687-97.
PMID: 11570869
Correolide is a novel immunosuppressant that inhibits the voltage-gated potassium channel K(v)1.3 [Felix et al. (1999) Biochemistry 38, 4922-4930]. [(3)H]Dihydrocorreolide (diTC) binds with high affinity to membranes expressing homotetrameric K(v)1.3...
4.
Grant S, Bansal A, Mitra A, Feighner S, Dai G, Kaczorowski G, et al.
Anal Biochem
. 2001 Jun;
294(1):27-35.
PMID: 11412002
Whole-cell functional assays are often used for high-throughput screening (HTS) of molecular targets such as ion channels and G-protein-coupled receptors. A common method for assaying the activity of these membrane...
5.
Garcia M, Gao Y, McManus O, Kaczorowski G
Toxicon
. 2001 Jan;
39(6):739-48.
PMID: 11137531
No abstract available.
6.
Vianna-Jorge R, Oliveira C, Garcia M, Kaczorowski G, Suarez-Kurtz G
Br J Pharmacol
. 2000 Oct;
131(4):772-8.
PMID: 11030727
Correolide (1 - 10 microM), a nortriterpene purified from Spachea correae and a selective blocker of Kv1 potassium channels, elicits repetitive twitching in guinea-pig ileum. This effect is not seen...
7.
Smith M, Warren V, Thomas B, Brochu R, Ertel E, Rohrer S, et al.
Biochemistry
. 2000 May;
39(18):5543-54.
PMID: 10820028
Nodulisporic acid (NA) is an indole diterpene fungal product with insecticidal activity. NA activates a glutamate-gated chloride channel (GluCl) in grasshopper neurons and potentiates channel opening by glutamate. The endectocide...
8.
Hanner M, Schmalhofer W, Green B, Bordallo C, Liu J, Slaughter R, et al.
J Biol Chem
. 1999 Aug;
274(36):25237-44.
PMID: 10464244
Correolide, a novel nortriterpene natural product, potently inhibits the voltage-gated potassium channel, K(v)1.3, and [(3)H]dihydrocorreolide (diTC) binds with high affinity (K(d) approximately 10 nM) to membranes from Chinese hamster ovary...
9.
Wanner S, Glossmann H, Knaus H, Baker R, Parsons W, Rupprecht K, et al.
Biochemistry
. 1999 Aug;
38(34):11137-46.
PMID: 10460170
The iminodihydroquinoline WIN 17317-3 was previously shown to inhibit selectively the voltage-gated potassium channels, K(v)1.3 and K(v)1.4 [Hill, R. J., et al. (1995) Mol. Pharmacol. 48, 98-104; Nguyen, A., et...
10.
Kaczorowski G, Garcia M
Curr Opin Chem Biol
. 1999 Jul;
3(4):448-58.
PMID: 10419851
Several important new findings have furthered the development of voltage-gated and calcium-activated potassium channel pharmacology. The molecular constituents of several members of these large ion channel families were identified. Small-molecule...