W A Schmalhofer
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Explore the profile of W A Schmalhofer including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
329
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Recent Articles
1.
McMillan L, Carr R, Young C, Astin J, Lowe R, Parker E, et al.
Mol Genet Genomics
. 2003 Jul;
270(1):9-23.
PMID: 12884010
The gene cluster required for paxilline biosynthesis in Penicillium paxilli contains two cytochrome P450 monooxygenase genes, paxP and paxQ. The primary sequences of both proteins are very similar to those...
2.
Schroeder N, Mullmann T, Schmalhofer W, Gao Y, Garcia M, Giangiacomo K
FEBS Lett
. 2002 Sep;
527(1-3):298-302.
PMID: 12220678
Iberiotoxin (IbTX) is a remarkably selective alpha-K toxin peptide (alpha-KTx) inhibitor of the maxi-K channel. In contrast, the highly homologous charybdotoxin inhibits both the maxi-K and K(V)1.3 channels with similar...
3.
Hanner M, Green B, Gao Y, Schmalhofer W, Matyskiela M, Durand D, et al.
Biochemistry
. 2001 Sep;
40(39):11687-97.
PMID: 11570869
Correolide is a novel immunosuppressant that inhibits the voltage-gated potassium channel K(v)1.3 [Felix et al. (1999) Biochemistry 38, 4922-4930]. [(3)H]Dihydrocorreolide (diTC) binds with high affinity to membranes expressing homotetrameric K(v)1.3...
4.
Hanner M, Schmalhofer W, Green B, Bordallo C, Liu J, Slaughter R, et al.
J Biol Chem
. 1999 Aug;
274(36):25237-44.
PMID: 10464244
Correolide, a novel nortriterpene natural product, potently inhibits the voltage-gated potassium channel, K(v)1.3, and [(3)H]dihydrocorreolide (diTC) binds with high affinity (K(d) approximately 10 nM) to membranes from Chinese hamster ovary...
5.
Felix J, Bugianesi R, Schmalhofer W, Borris R, Goetz M, Hensens O, et al.
Biochemistry
. 1999 Apr;
38(16):4922-30.
PMID: 10213593
A novel nortriterpene, termed correolide, purified from the tree Spachea correae, inhibits Kv1.3, a Shaker-type delayed rectifier potassium channel present in human T lymphocytes. Correolide inhibits 86Rb+ efflux through Kv1.3...
6.
Garcia M, Giangiacomo K, Hanner M, Knaus H, McManus O, Schmalhofer W, et al.
Methods Enzymol
. 1999 Jan;
294:274-87.
PMID: 9916233
No abstract available.
7.
Hanner M, Vianna-Jorge R, Kamassah A, Schmalhofer W, Knaus H, Kaczorowski G, et al.
J Biol Chem
. 1998 Jun;
273(26):16289-96.
PMID: 9632689
Coexpression of alpha and beta subunits of the high conductance Ca2+-activated K+ (maxi-K) channel leads to a 50-fold increase in the affinity for 125I-charybdotoxin (125I-ChTX) as compared with when the...
8.
Hanner M, Schmalhofer W, Munujos P, Knaus H, Kaczorowski G, Garcia M
Proc Natl Acad Sci U S A
. 1997 Apr;
94(7):2853-8.
PMID: 9096310
Transient expression of either alpha or alpha + beta subunits of the high-conductance Ca2+-activated K+ (maxi-K) channel has been achieved in COS-1 cells. Expression has been studied using charybdotoxin (ChTX),...
9.
Lee S, Hensens O, Helms G, Liesch J, ZINK D, Giacobbe R, et al.
J Nat Prod
. 1995 Dec;
58(12):1822-8.
PMID: 8691204
A novel oleic acid ester of the carotane sesquiterpene 14-hydroxy CAF-603 was isolated from Trichoderma virens grown in a solid brown rice-based medium, a solid millet-based medium, or a mannitol-based...
10.
Knaus H, Eberhart A, Koch R, Munujos P, Schmalhofer W, Warmke J, et al.
J Biol Chem
. 1995 Sep;
270(38):22434-9.
PMID: 7673230
Purified high conductance calcium-activated potassium (maxi-K) channels from tracheal smooth muscle have been shown to consist of a 60-70-kDa alpha subunit, encoded by the slo gene, and a 31-kDa beta...