G C Shore
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Explore the profile of G C Shore including associated specialties, affiliations and a list of published articles.
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87
Citations
1846
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Recent Articles
1.
Warr M, Shore G
Curr Oncol
. 2008 Dec;
15(6):256-61.
PMID: 19079626
Dynamic protein-protein interactions between proapoptotic and pro-survival Bcl-2 family members regulate outer-mitochondrial membrane permeabilization and cytochrome c release, key events in the path to apoptosis. Their relative levels often dictate...
2.
Heath-Engel H, Chang N, Shore G
Oncogene
. 2008 Oct;
27(50):6419-33.
PMID: 18955970
Apoptosis is essential for normal development and maintenance of homeostasis, and disruption of apoptotic pathways is associated with multiple disease states, including cancer. Although initially identified as central regulators of...
3.
Perez-Galan P, Roue G, Lopez-Guerra M, Nguyen M, Villamor N, Montserrat E, et al.
Leukemia
. 2008 Jul;
22(9):1712-20.
PMID: 18596739
Chronic lymphocytic leukemia (CLL) is a B-cell lymphoid neoplasm with deregulated apoptosis and overexpression of several antiapoptotic BCL-2 proteins. GX15-070/Obatoclax is a small-molecule BH3 mimetic compound that has shown activity...
4.
Heath-Engel H, Shore G
Cell Death Differ
. 2006 May;
13(8):1277-80.
PMID: 16710364
No abstract available.
5.
Rivera I, Shore G, Schleiff E
J Bioenerg Biomembr
. 2002 Jan;
32(1):111-21.
PMID: 11768756
We have cloned a 35-kDa protein from a mouse cDNA library with a 25% overall amino acid identity to yTom40 and 27% identity to nTom40. This homolog toTom40 was named...
6.
Breckenridge D, Shore G
Crit Rev Eukaryot Gene Expr
. 2001 Mar;
10(3-4):273-80.
PMID: 11272469
E1A and c-myc are oncogenes that can deregulate the cell cycle and promote transformation under conditions where normal cell-cycle checkpoints are inactivated. In situations where cell-cycle checkpoints are intact, the...
7.
Ruffolo S, Breckenridge D, Nguyen M, Goping I, Gross A, Korsmeyer S, et al.
Cell Death Differ
. 2001 Jan;
7(11):1101-8.
PMID: 11139284
In the absence of an apoptotic signal, BAX adopts a conformation that constrains the protein from integrating into mitochondrial membranes. Here, we show that caspases, including caspase-8, can initiate BAX...
8.
Heibein J, Goping I, Barry M, Pinkoski M, Shore G, Green D, et al.
J Exp Med
. 2000 Nov;
192(10):1391-402.
PMID: 11085742
Cytotoxic T lymphocytes (CTLs) destroy target cells through a mechanism involving the exocytosis of cytolytic granule components including granzyme B (grB) and perforin, which have been shown to induce apoptosis...
9.
Nguyen M, Breckenridge D, Ducret A, Shore G
Mol Cell Biol
. 2000 Aug;
20(18):6731-40.
PMID: 10958671
BAP31 is a 28-kDa integral membrane protein of the endoplasmic reticulum whose cytosolic domain contains two identical caspase recognition sites (AAVD.G) that are preferentially cleaved by initiator caspases, including caspase...
10.
Schleiff E, Silvius J, Shore G
J Cell Biol
. 1999 Jun;
145(5):973-8.
PMID: 10352015
Insertion of newly synthesized proteins into or across the mitochondrial outer membrane is initiated by import receptors at the surface of the organelle. Typically, this interaction directs the precursor protein...