G Byk
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Explore the profile of G Byk including associated specialties, affiliations and a list of published articles.
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20
Citations
235
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Recent Articles
1.
Marks V, Gottlieb H, Melman A, Byk G, Cohen S, Biali S
J Org Chem
. 2001 Oct;
66(20):6711-8.
PMID: 11578225
1,2,3,4,5,6,7,8-Octaethylanthracene (5), 1,2,3,4,6,7,8-heptaethylfluorene (7), and 1,2,3,4,5,6,7,8-octaethylfluorene (8) were synthesized by Friedel-Crafts ethylations of 9,10-dihydroanthracene and fluorene. MM3 calculations indicate that the two ethylated six-membered rings of 5 and 7 are...
2.
Wetzer B, Byk G, Frederic M, Airiau M, Blanche F, Pitard B, et al.
Biochem J
. 2001 Jun;
356(Pt 3):747-56.
PMID: 11389682
One of the main challenges of gene therapy remains the increase of gene delivery into eukaryotic cells. We tested whether intracellular DNA release, an essential step for gene transfer, could...
3.
Byk G, Wetzer B, Frederic M, Dubertret C, Pitard B, Jaslin G, et al.
J Med Chem
. 2000 Nov;
43(23):4377-87.
PMID: 11087563
We have designed and synthesized original cationic lipids for modulated release of DNA from cationic lipid/DNA complexes. Our rationale was that modulated degradation of the lipids during or after penetration...
4.
Soto J, Bessodes M, Pitard B, MAILHE P, Scherman D, Byk G
Bioorg Med Chem Lett
. 2000 Jun;
10(9):911-4.
PMID: 10853658
We have developed new DNA complexing amphiphile based on Hoechst 33258 interaction with DNA grooves. The synthesis and physicochemical characterisation of lipid/DNA complexes, as compared to that of classical lipopolyamine...
5.
Neves C, Byk G, Escriou V, Bussone F, Scherman D, Wils P
Bioconjug Chem
. 2000 Jan;
11(1):51-5.
PMID: 10639085
We have developed a chemical strategy for covalent coupling of fluorophores to plasmid DNA. A p-azido-tetrafluoro-benzyl-lissamine conjugate was synthesized and purified. This conjugate was used to covalently associate fluorescent molecules...
6.
Byk G, Gottlieb H, Herscovici J, Mirkin F
J Comb Chem
. 2000 Jan;
2(6):732-5.
PMID: 11126301
In the context of our high-throughput organic synthesis program, we have studied the reactivity of special beta-keto esters toward the Biginelli reaction. We have found that a cyclic beta-keto ester...
7.
Neves C, Escriou V, Byk G, Scherman D, Wils P
Cell Biol Toxicol
. 1999 Dec;
15(3):193-202.
PMID: 10580552
One of the major steps limiting nonviral gene transfer efficiency is the entry of plasmid DNA from the cytoplasm into the nucleus of the transfected cells. The nuclear localization signal...
8.
Schwartz B, Ivanov M, Pitard B, Escriou V, Rangara R, Byk G, et al.
Gene Ther
. 1999 Aug;
6(2):282-92.
PMID: 10435113
Cationic lipids can deliver genes efficiently in vitro, but are generally inhibited by the presence of serum, and their efficiency in vivo is much lower than in vitro. An attractive...
9.
Neves C, Byk G, Scherman D, Wils P
FEBS Lett
. 1999 Jul;
453(1-2):41-5.
PMID: 10403371
The nuclear localization signal (NLS) of the SV40 large T antigen efficiently induces nuclear entry of proteins. We have developed a strategy for covalent coupling of one or a controlled...
10.
Byk G, Soto J, Mattler C, Frederic M, Scherman D
Biotechnol Bioeng
. 1999 Apr;
61(2):81-7.
PMID: 10099500
The development of new gene delivery technologies is a prerequisite towards gene therapy clinical trials. Because gene delivery mediated by viral vectors remains of limited scope due to immunological and...