B Pitard
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Explore the profile of B Pitard including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
475
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Recent Articles
1.
Lefebvre M, Vignier N, Pitard B, Botelho-Nevers E, Wyplosz B, Cohen R, et al.
Infect Dis Now
. 2021 Mar;
51(4):319-333.
PMID: 33681861
At the end of December 2019, China notified the World Health Organization about a viral pneumonia epidemic soon to be named COVID-19, of which the infectious agent, SARS-CoV-2, was rapidly...
2.
Richard-Fiardo P, Cambien B, Pradelli E, Beilvert F, Pitard B, Schmid-Antomarchi H, et al.
Cancer Gene Ther
. 2011 Aug;
18(11):761-72.
PMID: 21869819
The lung is one target organ to which solid tumors frequently metastasize. Given the systemic adverse effects of currently available treatments, developing effective strategies of drug/gene delivery directly to the...
3.
Morille M, Passirani C, Letrou-Bonneval E, Benoit J, Pitard B
Int J Pharm
. 2009 Jun;
379(2):293-300.
PMID: 19505548
The main objective of gene therapy via a systemic pathway is the development of a stable and non-toxic gene vector that can encapsulate and deliver foreign genetic materials into specific...
4.
Pitard B, Oudrhiri N, Lambert O, Vivien E, Masson C, Wetzer B, et al.
J Gene Med
. 2001 Oct;
3(5):478-87.
PMID: 11601761
Background: Colloidal stability of lipid/DNA aggregates is a major requirement for cationic lipid-mediated transfection which is particularly difficult to fulfil at the high DNA concentrations used for in vivo gene...
5.
Wetzer B, Byk G, Frederic M, Airiau M, Blanche F, Pitard B, et al.
Biochem J
. 2001 Jun;
356(Pt 3):747-56.
PMID: 11389682
One of the main challenges of gene therapy remains the increase of gene delivery into eukaryotic cells. We tested whether intracellular DNA release, an essential step for gene transfer, could...
6.
Byk G, Wetzer B, Frederic M, Dubertret C, Pitard B, Jaslin G, et al.
J Med Chem
. 2000 Nov;
43(23):4377-87.
PMID: 11087563
We have designed and synthesized original cationic lipids for modulated release of DNA from cationic lipid/DNA complexes. Our rationale was that modulated degradation of the lipids during or after penetration...
7.
Leclercq F, Dubertret C, Pitard B, Scherman D, Herscovici J
Bioorg Med Chem Lett
. 2000 Jun;
10(11):1233-5.
PMID: 10866388
A safe and efficient synthesis of glycosylated polyethylenimine using titanium (IV) isopropoxide and sodium borohydride has been carried out as a substitute for the highly toxic sodium cyanoborohydride method currently...
8.
Soto J, Bessodes M, Pitard B, MAILHE P, Scherman D, Byk G
Bioorg Med Chem Lett
. 2000 Jun;
10(9):911-4.
PMID: 10853658
We have developed new DNA complexing amphiphile based on Hoechst 33258 interaction with DNA grooves. The synthesis and physicochemical characterisation of lipid/DNA complexes, as compared to that of classical lipopolyamine...
9.
Turek J, Dubertret C, Jaslin G, Antonakis K, Scherman D, Pitard B
J Gene Med
. 2000 Apr;
2(1):32-40.
PMID: 10765503
Background: Cationic lipids are the most widely used nonviral vectors for gene delivery. Upon complexation to DNA, they offer a nonimmunogenic alternative to viral gene transfer. Unfortunately, their in vivo...
10.
Kreiss P, Cameron B, Rangara R, MAILHE P, Airiau M, Scherman D, et al.
Nucleic Acids Res
. 1999 Sep;
27(19):3792-8.
PMID: 10481017
Clinical applications of gene therapy mainly depend on the development of efficient gene transfer vectors. Large DNA molecules can only be transfected into cells by using synthetic vectors such as...