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Frederic Rousseau

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Recent Articles
11.
Lopes J, Baudin C, Rousseau F, Roy H, Lestaevel P, Caer-Lorho S, et al.
BMJ Open . 2024 Jun; 14(6):e084285. PMID: 38904132
Objective: This study aimed at investigating the relationship between occupational exposure to external ionising radiation and central nervous system (CNS) tumours mortality in healthcare workers working in France. Design And...
12.
Princen K, Van Dooren T, van Gorsel M, Louros N, Yang X, Dumbacher M, et al.
Science . 2024 May; 384(6699):eadd6260. PMID: 38815015
Abnormal calcium signaling is a central pathological component of Alzheimer's disease (AD). Here, we describe the identification of a class of compounds called ReS19-T, which are able to restore calcium...
13.
Khanal S, Kim T, Begyn K, Duverger W, Kramer G, Brul S, et al.
Int J Food Microbiol . 2024 Apr; 418:110709. PMID: 38663147
Wet heat treatment is a commonly applied method in the food and medical industries for the inactivation of microorganisms, and bacterial spores in particular. While many studies have delved into...
14.
Louros N, Rousseau F, Schymkowitz J
Bioinformatics . 2024 Apr; 40(5). PMID: 38662570
Motivation: Proteins, the molecular workhorses of biological systems, execute a multitude of critical functions dictated by their precise three-dimensional structures. In a complex and dynamic cellular environment, proteins can undergo...
15.
Baudin C, Vacquier B, Thin G, Chenene L, Guersen J, Partarrieu I, et al.
J Radiol Prot . 2024 Apr; 44(2). PMID: 38569480
The number of healthcare workers occupationally exposed to ionizing radiation (IR) is increasing every year. As health effects from exposure to low doses IR have been reported, radiation protection (RP)...
16.
Orlando G, Serrano L, Schymkowitz J, Rousseau F
Bioinformatics . 2024 Mar; 40(4). PMID: 38514422
Motivation: Deep learning algorithms applied to structural biology often struggle to converge to meaningful solutions when limited data is available, since they are required to learn complex physical rules from...
17.
Louros N, Wilkinson M, Tsaka G, Ramakers M, Morelli C, Garcia T, et al.
Nat Commun . 2024 Feb; 15(1):1028. PMID: 38310108
Tauopathies encompass a group of neurodegenerative disorders characterised by diverse tau amyloid fibril structures. The persistence of polymorphism across tauopathies suggests that distinct pathological conditions dictate the adopted polymorph for...
18.
Duran-Romana R, Houben B, De Vleeschouwer M, Louros N, Wilson M, Matthijs G, et al.
Sci Adv . 2024 Jan; 10(5):eadk8173. PMID: 38295165
The tendency for proteins to form aggregates is an inherent part of every proteome and arises from the self-assembly of short protein segments called aggregation-prone regions (APRs). While posttranslational modifications...
19.
Libe-Philippot B, Lejeune A, Wierda K, Louros N, Erkol E, Vlaeminck I, et al.
Cell . 2023 Dec; 186(26):5766-5783.e25. PMID: 38134874
The enhanced cognitive abilities characterizing the human species result from specialized features of neurons and circuits. Here, we report that the hominid-specific gene LRRC37B encodes a receptor expressed in human...
20.
Tome S, Tsaka G, Ronisz A, Ospitalieri S, Gawor K, Gomes L, et al.
Mol Neurodegener . 2023 Sep; 18(1):71. PMID: 37777806
Background: Most Alzheimer's Disease (AD) cases also exhibit limbic predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides amyloid-β plaques and neurofibrillary tangles (NFTs) containing hyperphosphorylated tau (p-tau). LATE-NC is characterized...