Frederic Rousseau
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Explore the profile of Frederic Rousseau including associated specialties, affiliations and a list of published articles.
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189
Citations
8989
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Recent Articles
21.
Khodaparast L, Khodaparast L, Wu G, Michiels E, Gallardo R, Houben B, et al.
Nat Commun
. 2023 Sep;
14(1):5571.
PMID: 37689716
There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings. We have observed that certain beta-lactamases tend to aggregate, which...
22.
Louros N, Schymkowitz J, Rousseau F
Nat Rev Mol Cell Biol
. 2023 Sep;
24(12):912-933.
PMID: 37684425
Despite advances in machine learning-based protein structure prediction, we are still far from fully understanding how proteins fold into their native conformation. The conventional notion that polypeptides fold spontaneously to...
23.
Janssen K, Duran-Romana R, Bottu G, Guharoy M, Botzki A, Rousseau F, et al.
BMC Bioinformatics
. 2023 Jul;
24(1):287.
PMID: 37464277
Background: Next-generation sequencing technologies yield large numbers of genetic alterations, of which a subset are missense variants that alter an amino acid in the protein product. These variants can have...
24.
Heinzl N, Maritschnegg E, Koziel K, Schilhart-Wallisch C, Heinze G, Yang W, et al.
Oncogene
. 2023 Jul;
42(33):2473-2484.
PMID: 37402882
TP53 is the most commonly mutated gene in cancer and has been shown to form amyloid-like aggregates, similar to key proteins in neurodegenerative diseases. Nonetheless, the clinical implications of p53...
25.
Sonderby T, Louros N, Khodaparast L, Khodaparast L, Madsen D, Olsen W, et al.
J Mol Biol
. 2023 Jun;
435(11):168039.
PMID: 37330291
Functional bacterial amyloid provides structural stability in biofilm, making it a promising target for anti-biofilm therapeutics. Fibrils formed by CsgA, the major amyloid component in E. coli are extremely robust...
26.
Michiels E, Roose K, Gallardo R, Khodaparast L, Khodaparast L, van der Kant R, et al.
Nat Commun
. 2023 Jun;
14(1):3492.
PMID: 37311856
No abstract available.
27.
Wu G, Khodaparast L, Khodaparast L, De Vleeschouwer M, Louros N, Gallardo R, et al.
PLoS One
. 2023 Mar;
18(3):e0283674.
PMID: 37000776
The overconsumption and inappropriate use of antibiotics is escalating antibiotic resistance development, which is now one of the 10 top threats to global health. Introducing antibiotics with a novel mode...
28.
Naus E, Derweduwe M, Lampi Y, Claeys A, Pauwels J, Langenberg T, et al.
Cells
. 2023 Mar;
12(6).
PMID: 36980299
In malignant cancer, excessive amounts of mutant p53 often lead to its aggregation, a feature that was recently identified as druggable. Here, we describe that induction of a heat shock-related...
29.
Baudin C, Vacquier B, Thin G, Chenene L, Guersen J, Partarrieu I, et al.
Eur Radiol
. 2023 Mar;
33(8):5675-5684.
PMID: 36930262
Objectives: Health workers exposed to ionizing radiation account for + 50% of workers exposed to man-made radiation in France. Over the last decade, the use of radiation in medicine has...
30.
Bademosi A, Decet M, Kuenen S, Calatayud C, Swerts J, Gallego S, et al.
Neuron
. 2023 Feb;
111(9):1402-1422.e13.
PMID: 36827984
Neuronal activity causes use-dependent decline in protein function. However, it is unclear how this is coupled to local quality control mechanisms. We show in Drosophila that the endocytic protein Endophilin-A...