Frederic Rodriguez
Overview
Explore the profile of Frederic Rodriguez including associated specialties, affiliations and a list of published articles.
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29
Citations
148
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Recent Articles
1.
Hoffmann P, Azema-Despeyroux J, Goncalves F, Stamilla A, Saffon-Merceron N, Rodriguez F, et al.
Molecules
. 2024 Jul;
29(13).
PMID: 38999028
Tuberculosis is a serious public health problem worldwide. The search for new antibiotics has become a priority, especially with the emergence of resistant strains. A new family of imidazoquinoline derivatives,...
2.
Borie-Guichot M, Lan Tran M, Garcia V, Oukhrib A, Rodriguez F, Turrin C, et al.
Bioorg Chem
. 2024 Mar;
146:107295.
PMID: 38513326
A concise asymmetric synthesis of clickable enantiomeric pyrrolidines was achieved using Crabbé-Ma allenation. The synthesized iminosugars were grafted by copper-free strain-promoted alkyne-azide cycloaddition onto phosphorus dendrimers. The hexavalent and dodecavalent...
3.
Tamhaev R, Grosjean E, Ahamed H, Chebaiki M, Rodriguez F, Recchia D, et al.
Bioorg Chem
. 2023 Dec;
143:107032.
PMID: 38128204
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a worldwide scourge with more than 10 million people affected yearly. Among the proteins essential for the survival of Mtb, InhA has...
4.
Bossuat M, Rulliere P, Preuilh N, Peixoto A, Joly E, Gomez J, et al.
J Med Chem
. 2023 Oct;
66(20):13918-13945.
PMID: 37816126
A series of 25 chiral anti-cancer lipidic alkynylcarbinols (LACs) were devised by introducing an (hetero)aromatic ring between the aliphatic chain and the dialkynylcarbinol warhead. The resulting phenyl-dialkynylcarbinols (PACs) exhibit enhanced...
5.
Chebaiki M, Delfourne E, Tamhaev R, Danoun S, Rodriguez F, Hoffmann P, et al.
Eur J Med Chem
. 2023 Jul;
259:115646.
PMID: 37482022
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) affects 10 million people each year and the emergence of resistant TB augurs for a growing incidence. In the last 60 years, only...
6.
Levy T, Marchand L, Stroobant V, Pilotte L, Van den Eynde B, Rodriguez F, et al.
Bioorg Med Chem Lett
. 2021 Mar;
40:127910.
PMID: 33711443
Indoleamine 2,3-dioxygenase (IDO1) and tryptophane 2,3-dioxygenase (TDO) are two heme-containing enzymes which catalyze the conversion of tryptophan to N-formylkynurenine. Both enzymes are well establish therapeutic targets as important factors in...
7.
Castellan T, Garcia V, Rodriguez F, Fabing I, Shchukin Y, Lan Tran M, et al.
Org Biomol Chem
. 2020 Sep;
18(39):7852-7861.
PMID: 32975266
A concise and asymmetric synthesis of the enantiomeric pyrrolidines 2 and ent-2 are herein reported. Both enantiomers were assessed as β-GCase inhibitors. While compound ent-2 acted as a poor competitive...
8.
Assemat G, Balayssac S, Gilard V, Martins-Froment N, Fabing I, Rodriguez F, et al.
J Pharm Biomed Anal
. 2020 Sep;
191:113482.
PMID: 32898728
A sexual enhancer dietary supplement in pre-commercialization phase was analyzed. It contained the two phosphodiesterase-5 inhibitors (PDE-5i) sildenafil and methisosildenafil as major adulterants. Fourteen more sildenafil derivatives were detected and...
9.
Rodriguez F, Saffon N, Sammartino J, Degiacomi G, Pasca M, Lherbet C
Bioorg Chem
. 2019 Dec;
95:103498.
PMID: 31855823
Two macrocyclic derivatives based on the triclosan frame were designed and synthesized as inhibitors of Mycobacterium tuberculosis InhA enzyme. One of the two molecules M02 displayed promising inhibitory activity against...
10.
Castellan T, Santos C, Rodriguez F, Lepage M, Liang Y, Bodlenner A, et al.
Bioorg Med Chem Lett
. 2019 Nov;
30(2):126796.
PMID: 31757669
Dysregulation of the ceramide transport protein CERT is associated to diseases such as cancer. In search for new CERT START domain ligands, N-dodecyl-deoxynojirimycin (N-dodecyl-DNJ) iminosugar was found to display, as...