Fred W Perrino
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Explore the profile of Fred W Perrino including associated specialties, affiliations and a list of published articles.
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47
Citations
1962
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Recent Articles
1.
Venkatadri R, Sabapathy V, Dogan M, Mohammad S, Harvey S, Simpson S, et al.
Eur J Immunol
. 2022 Feb;
52(5):825-834.
PMID: 35112355
The Three Prime Repair EXonuclease I (TREX1) is critical for degrading post-apoptosis DNA. Mice expressing catalytically inactive TREX1 (TREX1 D18N) develop lupus-like autoimmunity due to chronic sensing of undegraded TREX1...
2.
Hemphill W, Simpson S, Liu M, Salsbury Jr F, Hollis T, Grayson J, et al.
Front Immunol
. 2021 Apr;
12:660184.
PMID: 33868310
Mutations in the TREX1 3' → 5' exonuclease are associated with a spectrum of autoimmune disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS-STING DNA-sensing pathway...
3.
Simpson S, Hemphill W, Hudson T, Perrino F
DNA Repair (Amst)
. 2020 Jul;
94:102894.
PMID: 32615442
The cytosolic Three prime Repair EXonuclease 1 (TREX1) is a powerful DNA-degrading enzyme required for clearing cytosolic DNA to prevent aberrant inflammation and autoimmunity. In the absence of TREX1 activity,...
4.
Simpson S, Rego S, Harvey S, Liu M, Hemphill W, Venkatadri R, et al.
J Immunol
. 2019 Dec;
204(2):348-359.
PMID: 31826941
Autoimmunity can result when cells fail to properly dispose of DNA. Mutations in the three-prime repair exonuclease 1 (TREX1) cause a spectrum of human autoimmune diseases resembling systemic lupus erythematosus....
5.
Hemphill W, Perrino F
Methods Enzymol
. 2019 Aug;
625:109-133.
PMID: 31455522
Three-prime Repair Exonuclease (TREX1) degrades ssDNA and dsDNA. TREX1 localizes to the perinuclear space in cells and degrades cytosolic DNA to prevent aberrant nucleic acid sensing and immune activation in...
6.
Rego S, Harvey S, Simpson S, Hemphill W, McIver Z, Grayson J, et al.
Autoimmunity
. 2018 Nov;
51(7):333-344.
PMID: 30422000
Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the...
7.
Mauney C, Perrino F, Hollis T
Biochemistry
. 2018 Nov;
57(47):6624-6636.
PMID: 30380297
The dNTP triphosphohydrolase SAMHD1 is a regulator of cellular dNTP pools. Given its central role in nucleotide metabolism, SAMHD1 performs important functions in cellular homeostasis, cell cycle regulation, and innate...
8.
Wang F, Zahid O, Swain B, Parsonage D, Hollis T, Harvey S, et al.
Nano Lett
. 2017 Oct;
17(11):7110-7116.
PMID: 28967259
Many regulated epigenetic elements and base lesions found in genomic DNA can both directly impact gene expression and play a role in disease processes. However, due to their noncanonical nature,...
9.
Mauney C, Rogers L, Harris R, Daniel L, Devarie-Baez N, Wu H, et al.
Antioxid Redox Signal
. 2017 Apr;
27(16):1317-1331.
PMID: 28398823
Aims: Proliferative signaling involves reversible posttranslational oxidation of proteins. However, relatively few molecular targets of these modifications have been identified. We investigate the role of protein oxidation in regulation of...
10.
Sakai T, Miyazaki T, Shin D, Kim Y, Qi C, Fariss R, et al.
J Autoimmun
. 2017 Mar;
81:13-23.
PMID: 28325644
TREX1/DNASE III, the most abundant 3'-5' DNA exonuclease in mammalian cells, is tail-anchored on the endoplasmic reticulum (ER). Mutations at the N-terminus affecting TREX1 DNase activity are associated with autoimmune...