Fred W Perrino
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Explore the profile of Fred W Perrino including associated specialties, affiliations and a list of published articles.
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47
Citations
1962
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Recent Articles
11.
Manils J, Casas E, Vina-Vilaseca A, Lopez-Cano M, Diez-Villanueva A, Gomez D, et al.
J Invest Dermatol
. 2016 Jul;
136(12):2345-2355.
PMID: 27365293
Trex2 is a keratinocyte-specific 3'-deoxyribonuclease that participates in the maintenance of skin homeostasis after DNA damage. Here, we show that this exonuclease is strongly upregulated in human psoriasis, a hyperproliferative...
12.
Manils J, Gomez D, Salla-Martret M, Fischer H, Fye J, Marzo E, et al.
Oncotarget
. 2015 Jun;
6(26):22375-96.
PMID: 26090614
TREX2 is a 3'-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic UV...
13.
Harris R, Perrino F, Shaban N
Cell Host Microbe
. 2015 Apr;
17(4):423-5.
PMID: 25856751
Viruses possess elaborate defensive mechanisms to evade host innate immune responses. In this issue of Cell Host & Microbe, Stavrou et al. (2015) reveal how the murine leukemia virus uses...
14.
Grieves J, Fye J, Harvey S, Grayson J, Hollis T, Perrino F
Proc Natl Acad Sci U S A
. 2015 Apr;
112(16):5117-22.
PMID: 25848017
The TREX1 gene encodes a potent DNA exonuclease, and mutations in TREX1 cause a spectrum of lupus-like autoimmune diseases. Most lupus patients develop autoantibodies to double-stranded DNA (dsDNA), but the...
15.
Davis R, Shaban N, Perrino F, Hollis T
Cell Cycle
. 2015 Feb;
14(4):668-73.
PMID: 25664393
RNA-DNA hybrids play essential roles in a variety of biological processes, including DNA replication, transcription, and viral integration. Ribonucleotides incorporated within DNA are hydrolyzed by RNase H enzymes in a...
16.
Fye J, Coffin S, Orebaugh C, Hollis T, Perrino F
J Biol Chem
. 2014 Mar;
289(16):11556-11565.
PMID: 24616097
TREX1 is a 3'-deoxyribonuclease that degrades single- and double-stranded DNA (ssDNA and dsDNA) to prevent inappropriate nucleic acid-mediated immune activation. More than 40 different disease-causing TREX1 mutations have been identified...
17.
Orebaugh C, Fye J, Harvey S, Hollis T, Wilkinson J, Perrino F
J Biol Chem
. 2013 Aug;
288(40):28881-92.
PMID: 23979357
TREX1 is an autonomous 3'-exonuclease that degrades DNA to prevent inappropriate immune activation. The TREX1 protein is composed of 314 amino acids; the N-terminal 242 amino acids contain the catalytic...
18.
Rice G, Reijns M, Coffin S, Forte G, Anderson B, Szynkiewicz M, et al.
Hum Mutat
. 2013 Apr;
34(8):1066-70.
PMID: 23592335
Aicardi-Goutières syndrome is an inflammatory disorder resulting from mutations in TREX1, RNASEH2A/2B/2C, SAMHD1, or ADAR1. Here, we provide molecular, biochemical, and cellular evidence for the pathogenicity of two synonymous variants...
19.
Bailey S, Harvey S, Perrino F, Hollis T
DNA Repair (Amst)
. 2011 Nov;
11(1):65-73.
PMID: 22071149
Mutations within the human TREX1 3' exonuclease are associated with Aicardi-Goutières Syndrome (AGS) and familial chilblain lupus (FCL). Both AGS and FCL are autoimmune diseases that result in increased levels...
20.
Powell R, Holland P, Hollis T, Perrino F
J Biol Chem
. 2011 Nov;
286(51):43596-43600.
PMID: 22069334
The SAMHD1 protein is an HIV-1 restriction factor that is targeted by the HIV-2 accessory protein Vpx in myeloid lineage cells. Mutations in the SAMHD1 gene cause Aicardi-Goutières syndrome, a...