Udesh de Silva
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Explore the profile of Udesh de Silva including associated specialties, affiliations and a list of published articles.
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6
Citations
421
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Recent Articles
1.
de Silva U, Zhou Z, Brown 2nd B
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2012 Aug;
68(Pt 8):854-9.
PMID: 22869109
Fibrillarin is the key methyltransferase associated with the C/D class of small nuclear ribonucleoproteins (snRNPs) and participates in the preliminary step of pre-ribosomal rRNA processing. This molecule is found in...
2.
de Silva U, Perrino F, Hollis T
Nucleic Acids Res
. 2009 Mar;
37(7):2411-7.
PMID: 19321497
The TREX enzymes process DNA as the major 3'-->5' exonuclease activity in mammalian cells. TREX2 and TREX1 are members of the DnaQ family of exonucleases and utilize a two metal...
3.
Perrino F, de Silva U, Harvey S, Pryor Jr E, Cole D, Hollis T
J Biol Chem
. 2008 Jun;
283(31):21441-52.
PMID: 18534978
The activity of human TREX2-catalyzed 3' --> 5'-deoxyribonuclease has been analyzed in steady-state and single turnover kinetic assays and in equilibrium DNA binding studies. These kinetic data provide evidence for...
4.
Lee-Kirsch M, Gong M, Chowdhury D, Senenko L, Engel K, Lee Y, et al.
Nat Genet
. 2007 Jul;
39(9):1065-7.
PMID: 17660818
TREX1 acts in concert with the SET complex in granzyme A-mediated apoptosis, and mutations in TREX1 cause Aicardi-Goutières syndrome and familial chilblain lupus. Here, we report monoallelic frameshift or missense...
5.
de Silva U, Choudhury S, Bailey S, Harvey S, Perrino F, Hollis T
J Biol Chem
. 2007 Feb;
282(14):10537-43.
PMID: 17293595
The TREX1 enzyme processes DNA ends as the major 3' --> 5' exonuclease activity in human cells. Mutations in the TREX1 gene are an underlying cause of the neurological brain...
6.
Chaudhry N, de Silva U, Smith G
Exp Neurol
. 2006 Jul;
202(1):238-49.
PMID: 16860320
Overexpression of nerve growth factor (NGF) using adenoviruses (Adts) after spinal cord injury induces extensive regeneration and sprouting of calcitonin-gene-related peptide immunoreactive (CGRP-IR) fibers, whereas overexpression of cell adhesion molecules...