Wayne O Hemphill
Overview
Explore the profile of Wayne O Hemphill including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
156
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0
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Recent Articles
1.
Hemphill W, Steiner H, Kominsky J, Wuttke D, Cech T
RNA
. 2024 May;
30(8):1089-1105.
PMID: 38760076
Many transcription factors (TFs) have been shown to bind RNA, leading to open questions regarding the mechanism(s) of this RNA binding and its role in regulating TF activities. Here, we...
2.
Hemphill W, Steiner H, Kominsky J, Wuttke D, Cech T
bioRxiv
. 2024 Apr;
PMID: 38562825
Many transcription factors (TFs) have been shown to bind RNA, leading to open questions regarding the mechanism(s) of this RNA binding and its role in regulating TF activities. Here we...
3.
Song J, Gooding A, Hemphill W, Love B, Robertson A, Yao L, et al.
Science
. 2023 Sep;
381(6664):1331-1337.
PMID: 37733873
Polycomb repressive complex 2 (PRC2) silences genes through trimethylation of histone H3K27. PRC2 associates with numerous precursor messenger RNAs (pre-mRNAs) and long noncoding RNAs (lncRNAs) with a binding preference for...
4.
Hemphill W, Voong C, Fenske R, Goodrich J, Cech T
Proc Natl Acad Sci U S A
. 2023 Jun;
120(26):e2220537120.
PMID: 37339225
We previously demonstrated that the polycomb repressive complex 2 chromatin-modifying enzyme can directly transfer between RNA and DNA without a free-enzyme intermediate state. Simulations suggested that such a direct transfer...
5.
Hemphill W, Fenske R, Gooding A, Cech T
Proc Natl Acad Sci U S A
. 2023 May;
120(23):e2220528120.
PMID: 37252986
The chromatin-modifying enzyme, Polycomb Repressive Complex 2 (PRC2), deposits the H3K27me3 epigenetic mark to negatively regulate expression at numerous target genes, and this activity has been implicated in embryonic development,...
6.
Song J, Gooding A, Hemphill W, Kasinath V, Cech T
bioRxiv
. 2023 Feb;
PMID: 36798278
One-sentence Summary: Cryo-EM structure of RNA-bound PRC2 dimer elucidates an unexpected mechanism of PRC2 inhibition by RNA.
7.
Amico G, Hemphill W, Severino M, Moratti C, Pascarella R, Bertamino M, et al.
Genes (Basel)
. 2022 Jul;
13(7).
PMID: 35885962
The TREX1 exonuclease degrades DNA to prevent aberrant nucleic-acid sensing through the cGAS-STING pathway, and dominant Aicardi-Goutières Syndrome type 1 (AGS1) represents one of numerous -related autoimmune diseases. Monoallelic mutations...
8.
Batalis S, Rogers L, Hemphill W, Mauney C, Ornelles D, Hollis T
Front Mol Biosci
. 2021 Sep;
8:724870.
PMID: 34513928
SAMHD1 activity is regulated by a network of mechanisms including phosphorylation, oxidation, oligomerization, and others. Significant questions remain about the effects of phosphorylation on SAMHD1 function and activity. We investigated...
9.
Hemphill W, Simpson S, Liu M, Salsbury Jr F, Hollis T, Grayson J, et al.
Front Immunol
. 2021 Apr;
12:660184.
PMID: 33868310
Mutations in the TREX1 3' → 5' exonuclease are associated with a spectrum of autoimmune disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS-STING DNA-sensing pathway...
10.
Simpson S, Hemphill W, Hudson T, Perrino F
DNA Repair (Amst)
. 2020 Jul;
94:102894.
PMID: 32615442
The cytosolic Three prime Repair EXonuclease 1 (TREX1) is a powerful DNA-degrading enzyme required for clearing cytosolic DNA to prevent aberrant inflammation and autoimmunity. In the absence of TREX1 activity,...