Frauke van Bebber
Overview
Explore the profile of Frauke van Bebber including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
14
Citations
620
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hu Y, Hruscha A, Pan C, Schifferer M, Schmidt M, Nuscher B, et al.
Mol Neurodegener
. 2024 Jun;
19(1):50.
PMID: 38902734
Background: The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm. However, TDP-43 gain of function in the cytoplasm is still...
2.
Schmidt A, Hrupka B, van Bebber F, Sunil Kumar S, Feng X, Tschirner S, et al.
J Clin Invest
. 2024 Jun;
134(16).
PMID: 38888964
The β-secretase β-site APP cleaving enzyme (BACE1) is a central drug target for Alzheimer's disease. Clinically tested, BACE1-directed inhibitors also block the homologous protease BACE2. Yet little is known about...
3.
Hipke K, Pitter B, Hruscha A, van Bebber F, Modic M, Bansal V, et al.
Front Cell Dev Biol
. 2023 Jun;
11:1169962.
PMID: 37384248
Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear...
4.
Zambusi A, Novoselc K, Hutten S, Kalpazidou S, Koupourtidou C, Schieweck R, et al.
Nat Neurosci
. 2022 Nov;
25(12):1608-1625.
PMID: 36424432
Decreasing the activation of pathology-activated microglia is crucial to prevent chronic inflammation and tissue scarring. In this study, we used a stab wound injury model in zebrafish and identified an...
5.
Eichner R, Heider M, Fernandez-Saiz V, van Bebber F, Garz A, Lemeer S, et al.
Nat Med
. 2016 Jun;
22(7):735-43.
PMID: 27294876
Immunomodulatory drugs (IMiDs), such as thalidomide and its derivatives lenalidomide and pomalidomide, are key treatment modalities for hematologic malignancies, particularly multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon (CRBN),...
6.
Halder R, Hennion M, Vidal R, Shomroni O, Rahman R, Rajput A, et al.
Nat Neurosci
. 2015 Dec;
19(1):102-10.
PMID: 26656643
The ability to form memories is a prerequisite for an organism's behavioral adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin...
7.
Fleck D, van Bebber F, Colombo A, Galante C, Schwenk B, Rabe L, et al.
J Neurosci
. 2013 May;
33(18):7856-69.
PMID: 23637177
Proteolytic shedding of cell surface proteins generates paracrine signals involved in numerous signaling pathways. Neuregulin 1 (NRG1) type III is involved in myelination of the peripheral nervous system, for which...
8.
Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, et al.
Proc Natl Acad Sci U S A
. 2013 Mar;
110(13):4986-91.
PMID: 23457265
Mutations in the Tar DNA binding protein of 43 kDa (TDP-43; TARDBP) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43(+) inclusions (FTLD-TDP). To determine the...
9.
Hogl S, van Bebber F, Dislich B, Kuhn P, Haass C, Schmid B, et al.
Proteomics
. 2013 Mar;
13(9):1519-27.
PMID: 23457027
The aspartyl protease BACE1 cleaves neuregulin 1 and is involved in myelination and is a candidate drug target for Alzheimer's disease, where it acts as the β-secretase cleaving the amyloid...
10.
van Bebber F, Hruscha A, Willem M, Schmid B, Haass C
J Neurochem
. 2013 Feb;
127(4):471-81.
PMID: 23406323
Alzheimer's disease is the most frequent dementia. Pathologically, Alzheimer's disease is characterized by the accumulation of senile plaques composed of amyloid β-peptide (Aβ). Two proteases, β- and γ-secretase proteolytically generate...