Frans M van der Kloet
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Explore the profile of Frans M van der Kloet including associated specialties, affiliations and a list of published articles.
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10
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258
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Recent Articles
1.
Llambrich M, van der Kloet F, Semente L, Rodrigues A, Samanipour S, Stefanuto P, et al.
Brief Bioinform
. 2025 Mar;
26(2).
PMID: 40037642
Comprehensive 2D gas chromatography coupled with mass spectrometry (GC × GC-MS) is a powerful analytical technique. However, the complexity and volume of data generated pose significant challenges for data processing...
2.
Kortbeek R, Galland M, Muras A, van der Kloet F, Andre B, Heilijgers M, et al.
BMC Plant Biol
. 2021 Jul;
21(1):315.
PMID: 34215189
Background: Plant-produced specialised metabolites are a powerful part of a plant's first line of defence against herbivorous insects, bacteria and fungi. Wild ancestors of present-day cultivated tomato produce a plethora...
3.
Modi B, Khan H, van der Lee R, Wasim M, Haaxma C, Richmond P, et al.
Mol Genet Metab Rep
. 2021 May;
27:100761.
PMID: 33996490
Guanidinoacetate methyltransferase (GAMT) deficiency is a creatine deficiency disorder and an inborn error of metabolism presenting with progressive intellectual and neurological deterioration. As most cases are identified and treated in...
4.
van der Kloet F, Buurmans J, Jonker M, Smilde A, Westerhuis J
PLoS Comput Biol
. 2020 Sep;
16(9):e1008295.
PMID: 32997685
The field of transcriptomics uses and measures mRNA as a proxy of gene expression. There are currently two major platforms in use for quantifying mRNA, microarray and RNA-Seq. Many comparative...
5.
van der Kloet F, Sebastian-Leon P, Conesa A, Smilde A, Westerhuis J
BMC Bioinformatics
. 2016 Jun;
17 Suppl 5:195.
PMID: 27294690
Background: Joint and individual variation explained (JIVE), distinct and common simultaneous component analysis (DISCO) and O2-PLS, a two-block (X-Y) latent variable regression method with an integral OSC filter can all...
6.
Gonzalez O, Van Vliet M, Damen C, van der Kloet F, Vreeken R, Hankemeier T
Anal Chem
. 2015 May;
87(12):5921-9.
PMID: 25965142
The possible presence of matrix effect is one of the main concerns in liquid chromatography-mass spectrometry (LC-MS)-driven bioanalysis due to its impact on the reliability of the obtained quantitative results....
7.
Smit S, Szymanska E, Kunz I, Gomez Roldan V, van Tilborg M, Weber P, et al.
Mol Nutr Food Res
. 2014 Jul;
58(11):2111-21.
PMID: 25045152
Scope: Genistein from foods or supplements is metabolized by the gut microbiota and the human body, thereby releasing many different metabolites into systemic circulation. The order of their appearance in...
8.
van der Kloet F, Hendriks M, Hankemeier T, Reijmers T
Anal Chim Acta
. 2013 Oct;
801:34-42.
PMID: 24139572
Because of its high sensitivity and specificity, hyphenated mass spectrometry has become the predominant method to detect and quantify metabolites present in bio-samples relevant for all sorts of life science...
9.
Gonzalez-Covarrubias V, Beekman M, Uh H, Dane A, Troost J, Paliukhovich I, et al.
Aging Cell
. 2013 Mar;
12(3):426-34.
PMID: 23451766
Middle-aged offspring of nonagenarians, as compared to their spouses (controls), show a favorable lipid metabolism marked by larger LDL particle size in men and lower total triglyceride levels in women....
10.
Koek M, van der Kloet F, Kleemann R, Kooistra T, Verheij E, Hankemeier T
Metabolomics
. 2011 Apr;
7(1):1-14.
PMID: 21461033
Due to the complexity of typical metabolomics samples and the many steps required to obtain quantitative data in GC × GC-MS consisting of deconvolution, peak picking, peak merging, and integration,...