Frans C Schuit
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Explore the profile of Frans C Schuit including associated specialties, affiliations and a list of published articles.
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20
Citations
1474
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Recent Articles
1.
Cheng-Xue R, Gomez-Ruiz A, Antoine N, Noel L, Chae H, Ravier M, et al.
Diabetes
. 2013 Feb;
62(5):1612-22.
PMID: 23382449
We evaluated the role of ATP-sensitive K⁺ (K(ATP)) channels, somatostatin, and Zn²⁺ in the control of glucagon secretion from mouse islets. Switching from 1 to 7 mmol/L glucose inhibited glucagon...
2.
Ravier M, Daro D, Roma L, Jonas J, Cheng-Xue R, Schuit F, et al.
Diabetes
. 2011 Sep;
60(10):2533-45.
PMID: 21885870
Objective: Sarco-endoplasmic reticulum Ca(2+)-ATPase 2b (SERCA2b) and SERCA3 pump Ca(2+) in the endoplasmic reticulum (ER) of pancreatic β-cells. We studied their role in the control of the free ER Ca(2+)...
3.
Lehnert S, Kapitonov V, Thilakarathne P, Schuit F
BMC Genomics
. 2011 May;
12:257.
PMID: 21605348
Background: The total number of miRNA genes in a genome, expression of which is responsible for the miRNA repertoire of an organism, is not precisely known. Moreover, the question of...
4.
Declercq J, Kumar A, Gysemans C, Di Pietro C, Schraenen A, Chintinne M, et al.
Cell Transplant
. 2011 Feb;
20(8):1285-97.
PMID: 21294959
Pleomorphic adenoma gene-like 1 (PLAGL1) has been linked to transient neonatal diabetes mellitus. Here, we investigated the role of the related pleomorphic adenoma gene 1 (PLAG1) in glucose homeostasis. PLAG1...
5.
Colsoul B, Schraenen A, Lemaire K, Quintens R, Van Lommel L, Segal A, et al.
Proc Natl Acad Sci U S A
. 2010 Mar;
107(11):5208-13.
PMID: 20194741
Glucose homeostasis is critically dependent on insulin release from pancreatic beta-cells, which is strictly regulated by glucose-induced oscillations in membrane potential (V(m)) and the cytosolic calcium level ([Ca(2+)](cyt)). We propose...
6.
Maiti M, Nauwelaerts K, Lescrinier E, Schuit F, Herdewijn P
Biochem Biophys Res Commun
. 2010 Jan;
392(4):572-6.
PMID: 20097176
MicroRNAs (miRNAs) are a class of 19-25 nt long non-coding RNAs that regulate gene expression post-transcriptionally by binding with partially complementary sequences in the 3'-untranslated region (3'-UTR) and inhibiting mRNA...
7.
Boni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier D, Prazak R, et al.
Endocrinology
. 2009 Oct;
150(12):5218-29.
PMID: 19819943
Islets of patients with type 2 diabetes mellitus (T2DM) display features of an inflammatory process including elevated levels of the cytokine IL-1beta, various chemokines, and macrophages. IL-1beta is a master...
8.
Nicolson T, Bellomo E, Wijesekara N, Loder M, Baldwin J, Gyulkhandanyan A, et al.
Diabetes
. 2009 Jun;
58(9):2070-83.
PMID: 19542200
Objective: Zinc ions are essential for the formation of hexameric insulin and hormone crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the SLC30A8 gene, encoding the secretory granule zinc transporter...
9.
Lehnert S, Van Loo P, Thilakarathne P, Marynen P, Verbeke G, Schuit F
PLoS One
. 2009 Feb;
4(2):e4456.
PMID: 19209240
This paper connects Alu repeats, the most abundant repetitive elements in the human genome and microRNAs, small RNAs that alter gene expression at the post-transcriptional level. Base-pair complementarity could be...
10.
Ellingsgaard H, Ehses J, Hammar E, Van Lommel L, Quintens R, Martens G, et al.
Proc Natl Acad Sci U S A
. 2008 Aug;
105(35):13163-8.
PMID: 18719127
Interleukin-6 (IL-6) is systemically elevated in obesity and is a predictive factor to develop type 2 diabetes. Pancreatic islet pathology in type 2 diabetes is characterized by reduced beta-cell function...