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Roel Quintens

Explore the profile of Roel Quintens including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 53
Citations 1646
Followers 0
Related Specialties
Radiology
Science
General Medicine
Top 10 Co-Authors
Sarah Baatout
Ann Janssen
Arlette Michaux
Kevin Tabury
Leentje Van Lommel
Mieke Verslegers
Marjan Moreels
Frans Schuit
Mohammed A Benotmane
Mohammed Abderrafi Benotmane
Published In
Int J Radiat Biol
PLoS One
Diabetes
Proc Natl Acad Sci U S A
Front Physiol
Affiliations
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Recent Articles
1.
A human-specific, concerted repression of microcephaly genes contributes to radiation-induced growth defects in cortical organoids
Ribeiro J, Etlioglu E, Buset J, Janssen A, Puype H, Berden L, et al.
iScience . 2025 Feb; 28(2):111853. PMID: 39967878
Prenatal radiation-induced DNA damage poses a significant threat to neurodevelopment, resulting in microcephaly which primarily affects the cerebral cortex. So far, mechanistic studies were done in rodents. Here, we leveraged...
2.
Monitoring functional immune responses with a cytokine release assay: ISS flight hardware design and experimental protocol for whole blood cultures executed under microgravity conditions
Buchheim J, Feuerecker M, Balsamo M, Vukich M, Van Walleghem M, Tabury K, et al.
Front Physiol . 2024 Jan; 14:1322852. PMID: 38288353
Long-term space missions trigger a prolonged neuroendocrine stress response leading to immune system dysregulation evidenced by susceptibility to infections, viral reactivation, and skin irritations. However, due to existing technical constraints,...
3.
DNA damage and repair: underlying mechanisms leading to microcephaly
Ribeiro J, Altinisik N, Rajan N, Verslegers M, Baatout S, Gopalakrishnan J, et al.
Front Cell Dev Biol . 2023 Oct; 11:1268565. PMID: 37881689
DNA-damaging agents and endogenous DNA damage constantly harm genome integrity. Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in repairing lesions and preventing mutations in the...
4.
An integrative systems biology strategy to support the development of adverse outcome pathways (AOPs): a case study on radiation-induced microcephaly
Jaylet T, Quintens R, Armant O, Audouze K
Front Cell Dev Biol . 2023 Jul; 11:1197204. PMID: 37427375
Adverse Outcome Pathways (AOPs) are useful tools for assessing the potential risks associated with exposure to various stressors, including chemicals and environmental contaminants. They provide a framework for understanding the...
5.
Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning
Jaylet T, Quintens R, Benotmane M, Luukkonen J, Tanaka 3rd I, Ibanez C, et al.
Int J Radiat Biol . 2022 Aug; 98(12):1752-1762. PMID: 35947014
Background: Brain development during embryogenesis and in early postnatal life is particularly complex and involves the interplay of many cellular processes and molecular mechanisms, making it extremely vulnerable to exogenous...
6.
PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance
Tabury K, Monavarian M, Listik E, Shelton A, Choi A, Quintens R, et al.
Life Sci Alliance . 2022 Jul; 5(11). PMID: 35820706
Metastatic growth of ovarian cancer cells into the peritoneal cavity requires adaptation to various cellular stress factors to facilitate cell survival and growth. Here, we demonstrate the role of PVT1,...
7.
Fractionated irradiation of MCF7 breast cancer cells rewires a gene regulatory circuit towards a treatment-resistant stemness phenotype
Inalegwu A, Cuypers B, Claesen J, Janssen A, Coolkens A, Baatout S, et al.
Mol Oncol . 2022 May; 16(19):3410-3435. PMID: 35579852
Radiotherapy is the standard of care for breast cancer. However, surviving radioresistant cells can repopulate following treatment and provoke relapse. Better understanding of the molecular mechanisms of radiation resistance may...
8.
A systems radiation biology approach to unravel the role of chronic low-dose-rate gamma-irradiation in inducing premature senescence in endothelial cells
Babini G, Baiocco G, Barbieri S, Morini J, Sangsuwan T, Haghdoost S, et al.
PLoS One . 2022 Mar; 17(3):e0265281. PMID: 35286349
Purpose: The aim of this study was to explore the effects of chronic low-dose-rate gamma-radiation at a multi-scale level. The specific objective was to obtain an overall view of the...
9.
High-LET Carbon and Iron Ions Elicit a Prolonged and Amplified p53 Signaling and Inflammatory Response Compared to low-LET X-Rays in Human Peripheral Blood Mononuclear Cells
Macaeva E, Tabury K, Michaux A, Janssen A, Averbeck N, Moreels M, et al.
Front Oncol . 2021 Dec; 11:768493. PMID: 34888245
Understanding the differences in biological response to photon and particle radiation is important for optimal exploitation of particle therapy for cancer patients, as well as for the adequate application of...
10.
Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer's disease
Coninx E, Chew Y, Yang X, Guo W, Coolkens A, Baatout S, et al.
Aging (Albany NY) . 2020 Oct; 12(20):20817-20834. PMID: 33082299
Epigenetic clocks are based on age-associated changes in DNA methylation of CpG-sites, which can accurately measure chronological age in different species. Recently, several studies have indicated that the difference between...