Patrick Gilon
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Explore the profile of Patrick Gilon including associated specialties, affiliations and a list of published articles.
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55
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1587
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Recent Articles
1.
Hewawasam N, Sarkar D, Bolton O, Delishaj B, Almutairi M, King A, et al.
J Endocrinol
. 2024 Sep;
263(2).
PMID: 39292603
LEAP2, a liver-derived antagonist for the ghrelin receptor, GHSR1a, counteracts the effects of ghrelin on appetite and energy balance. Less is known about its impact on blood glucose-regulating hormones from...
2.
Boothe T, Lim G, Cen H, Skovso S, Piske M, Li S, et al.
Mol Metab
. 2024 Apr;
83:101935.
PMID: 38604236
No abstract available.
3.
Ramirez M, Bastien E, Chae H, Gianello P, Gilon P, Bouzin C
Islets
. 2024 Jan;
16(1):2298518.
PMID: 38267218
Pancreatic islet transplantation is a promising treatment for type 1 diabetes, but the survival and function of transplanted islets are hindered by the loss of extracellular matrix (ECM) during islet...
4.
Zaimia N, Obeid J, Varrault A, Sabatier J, Broca C, Gilon P, et al.
Cell Rep
. 2023 Oct;
42(11):113326.
PMID: 37897727
Glucagon-like peptide 1 (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIPR) receptors are G-protein-coupled receptors involved in glucose homeostasis. Diabetogenic conditions decrease β-arrestin 2 (ARRB2) levels in human islets. In mouse β...
5.
Zhang I, Herrmann A, Leon J, Jeyarajan S, Arunagiri A, Arvan P, et al.
J Biol Chem
. 2023 Jul;
299(8):105065.
PMID: 37468098
Pancreatic beta cells maintain glucose homeostasis by secreting pulses of insulin in response to a rise in plasma glucose. Pulsatile insulin secretion occurs as a result of glucose-induced oscillations in...
6.
Li M, Zhang R, Ge Q, Yue L, Ma D, Khattab F, et al.
Int J Mol Sci
. 2023 Jun;
24(11).
PMID: 37298086
Loss of the β cell population is a crucial feature of type 2 diabetes. Restoring the β cell mass by stimulating β cell proliferation and preventing its apoptosis was proposed...
7.
Gorgogietas V, Rajaei B, Heeyoung C, Santacreu B, Marin-Canas S, Salpea P, et al.
Diabetologia
. 2023 Mar;
66(7):1306-1321.
PMID: 36995380
Aims/hypothesis: Wolfram syndrome is a rare autosomal recessive disorder caused by pathogenic variants in the WFS1 gene. It is characterised by insulin-dependent diabetes mellitus, optic nerve atrophy, diabetes insipidus, hearing...
8.
Tariq M, de Souza A, Bensellam M, Chae H, Jaffredo M, Close A, et al.
Diabetologia
. 2022 Dec;
66(4):709-723.
PMID: 36459178
Aims/hypothesis: The rapid remission of type 2 diabetes by a diet very low in energy correlates with a marked improvement in glucose-stimulated insulin secretion (GSIS), emphasising the role of beta...
9.
Fantuzzi F, Toivonen S, Schiavo A, Chae H, Tariq M, Sawatani T, et al.
Front Cell Dev Biol
. 2022 Sep;
10:967765.
PMID: 36060810
differentiation of human induced pluripotent stem cells (iPSCs) into beta cells represents an important cell source for diabetes research. Here, we fully characterized iPSC-derived beta cell function and in humanized...
10.
Singh B, Khattab F, Gilon P
Mol Metab
. 2022 Apr;
61:101495.
PMID: 35421610
Objective: The mechanisms by which glucose stimulates insulin secretion from β-cells are well established and involve inhibition of ATP-sensitive K (K) channels, followed by a rise in [Ca] that triggers...