Frans C Schuit
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Explore the profile of Frans C Schuit including associated specialties, affiliations and a list of published articles.
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Recent Articles
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Van Lommel L, Janssens K, Quintens R, Tsukamoto K, Vander Mierde D, Lemaire K, et al.
Diabetes
. 2006 Nov;
55(12):3214-20.
PMID: 17130463
Task division in multicellular organisms ensures that differentiated cell types produce cell-specific proteins that fulfill tasks for the whole organism. In some cases, the encoded mRNA species is so abundant...
13.
Vander Mierde D, Scheuner D, Quintens R, Patel R, Song B, Tsukamoto K, et al.
Endocrinology
. 2006 Nov;
148(2):609-17.
PMID: 17082262
Both the rate of overall translation and the specific acceleration of proinsulin synthesis are known to be glucose-regulated processes in the beta-cell. In this study, we propose that glucose-induced stimulation...
14.
Ivarsson R, Quintens R, Dejonghe S, Tsukamoto K, In t Veld P, Renstrom E, et al.
Diabetes
. 2005 Jun;
54(7):2132-42.
PMID: 15983215
Cellular redox state is an important metabolic variable, influencing many aspects of cell function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH as a candidate signaling...
15.
Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers J, Tsukamoto K, et al.
Nat Med
. 2005 Jun;
11(7):757-64.
PMID: 15980866
Type 2 diabetes is a disorder of hyperglycemia resulting from failure of beta cells to produce adequate insulin to accommodate an increased metabolic demand. Here we show that regulation of...
16.
Hinke S, Hellemans K, Schuit F
J Physiol
. 2004 Jun;
558(Pt 2):369-80.
PMID: 15181163
It is well established that the acute rise in plasma glucose and in the incretin hormones glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (7-36) amide (GLP-1), as occurs during a...
17.
Viollet B, Andreelli F, Jorgensen S, Perrin C, Geloen A, Flamez D, et al.
J Clin Invest
. 2003 Jan;
111(1):91-8.
PMID: 12511592
AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid metabolism. To better understand the physiological role of AMPK, we generated a knockout mouse model in...
18.
Flamez D, Berger V, Kruhoffer M, Orntoft T, Pipeleers D, Schuit F
Diabetes
. 2002 Jun;
51(7):2018-24.
PMID: 12086928
The molecular mechanisms mediating acute regulation of insulin release by glucose are partially known. The process involves at least two pathways that can be discriminated on basis of their (in)dependence...
19.
Weets I, Siraux V, Daubresse J, De Leeuw I, Fery F, Keymeulen B, et al.
J Clin Endocrinol Metab
. 2002 Jun;
87(6):2597-605.
PMID: 12050221
We investigated inaugural disease phenotype in relation to the presence or absence of diabetes-associated autoantibodies and human leukocyte antigen (HLA) DQ risk genotypes in adult-onset diabetic patients. Blood samples and...
20.
Van der Auwera B, Schuit F, Weets I, Ivens A, Van Autreve J, Gorus F
Hum Immunol
. 2002 Mar;
63(1):40-50.
PMID: 11916169
HLA-DQ genotyping remains the cornerstone of genetic risk stratification in type I diabetes prediction and prevention studies. We developed a genetic screening strategy for predisposition to type I diabetes in...