Frank U Muller
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Explore the profile of Frank U Muller including associated specialties, affiliations and a list of published articles.
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46
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918
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Recent Articles
1.
Herting J, Berg A, Hadova K, Heinick A, Konig S, Kuhlmann M, et al.
J Mol Cell Cardiol Plus
. 2025 Jan;
3():100030.
PMID: 39803363
Protein phosphatase 2A (PP2A) plays a central role in myocardial ischemia-reperfusion (I/R) injury. Several studies showed a detrimental function of PP2A by using either overexpression models of the catalytic subunit...
2.
Herting J, Konig J, Hadova K, Heinick A, Muller F, Pauls P, et al.
Front Cardiovasc Med
. 2023 Oct;
10:1239555.
PMID: 37868783
Background: The activity, localization, and substrate specificity of the protein phosphatase 2A (PP2A) heterotrimer are controlled by various regulatory B subunits. PR72 belongs to the B'' gene family and has...
3.
Reyes Gaido O, Pavlaki N, Granger J, Mesubi O, Liu B, Lin B, et al.
Sci Transl Med
. 2023 Jun;
15(701):eabq7839.
PMID: 37343080
Ca/calmodulin-dependent protein kinase II (CaMKII) hyperactivity causes cardiac arrhythmias, a major source of morbidity and mortality worldwide. Despite proven benefits of CaMKII inhibition in numerous preclinical models of heart disease,...
4.
Bogeholz N, Knappe V, Pauls P, Schulte J, Goldhaber J, Muller F, et al.
Int J Cardiol Heart Vasc
. 2023 Jan;
44:101168.
PMID: 36620202
Aims: Na/Ca exchanger (NCX) upregulation in cardiac diseases like heart failure promotes as an independent proarrhythmic factor early and delayed afterdepolarizations (EADs/DADs) on the single cell level. Consequently, NCX inhibition...
5.
Glaser D, Heinick A, Herting J, Massing F, Muller F, Pauls P, et al.
J Biol Chem
. 2022 Aug;
298(9):102362.
PMID: 35963431
The activity of protein phosphatase 2A (PP2A) is determined by the expression and localization of the regulatory B-subunits. PP2A-B56α is the dominant isoform of the B'-family in the heart. Its...
6.
Pluteanu F, Boknik P, Heinick A, Konig C, Muller F, Weidlich A, et al.
Am J Physiol Heart Circ Physiol
. 2022 Feb;
322(3):H427-H441.
PMID: 35119335
Protein phosphatase 2A (PP2A) represents a heterotrimer that is responsible for the dephosphorylation of important regulatory myocardial proteins. This study was aimed to test whether the phosphorylation of PP2A-B56α at...
7.
Bollmann P, Werner F, Jaron M, Bruns T, Wache H, Runte J, et al.
Front Pharmacol
. 2021 Feb;
11:591773.
PMID: 33597873
As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated mice with cardiac-specific overexpression of PP2Cβ (PP2C-TG) and...
8.
Pluteanu F, Seidl M, Hamer S, Scholz B, Muller F
J Am Heart Assoc
. 2020 Nov;
9(23):e016144.
PMID: 33191843
BACKGROUND Transgenic mice (TG) with heart-directed overexpresion of the isoform of the transcription factor cyclic adenosine monophosphate response element modulator (CREM), CREM-IbΔC-X, display spontaneous atrial fibrillation (AF) and action potential...
9.
Seidl M, Fels B, Kranick D, Sternberg A, Grimm K, Stumpel F, et al.
FASEB J
. 2020 Jul;
34(8):11272-11291.
PMID: 32602979
ICER (inducible cAMP early repressor) isoforms are transcriptional repressors encoded by the Crem (cAMP responsive element modulator) gene. They were linked to the regulation of a multitude of cellular processes...
10.
Heinick A, Pluteanu F, Hermes C, Klemme A, Domnik M, Husser X, et al.
FASEB J
. 2020 Jun;
34(8):10489-10504.
PMID: 32579290
Adenylyl cyclases (AC) are essential for the normal and pathophysiological response of many cells. In cardiomyocytes, the predominant AC isoforms are AC5 and AC6. Specific AC5 inhibition was suggested as...