Uwe Kirchhefer
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Explore the profile of Uwe Kirchhefer including associated specialties, affiliations and a list of published articles.
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65
Citations
732
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Recent Articles
1.
Herting J, Berg A, Hadova K, Heinick A, Konig S, Kuhlmann M, et al.
J Mol Cell Cardiol Plus
. 2025 Jan;
3():100030.
PMID: 39803363
Protein phosphatase 2A (PP2A) plays a central role in myocardial ischemia-reperfusion (I/R) injury. Several studies showed a detrimental function of PP2A by using either overexpression models of the catalytic subunit...
2.
Pham T, Rayo Abella L, Hadova K, Klimas J, Dhein S, Pockes S, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2024 Dec;
PMID: 39729205
There is a controversy whether histamine H-receptor activation raises or lowers or does not affect contractility in the human heart. Therefore, we studied stimulation of H-receptors in isolated electrically stimulated...
3.
Schlicht J, Ahlrep U, Hofmann B, Kirchhefer U, Neumann J, Gergs U
Naunyn Schmiedebergs Arch Pharmacol
. 2024 Dec;
PMID: 39661142
Clozapine is an atypical antipsychotic (neuroleptic) drug. Clozapine binds to H-histamine receptors in vitro. We wanted to test the hypothesis that clozapine might be a functional antagonist at human cardiac...
4.
Pluteanu F, Glaser D, Massing F, Schulte J, Kirchhefer U
Front Cardiovasc Med
. 2024 Jun;
11:1419597.
PMID: 38863902
Background: Protein phosphatase 2A (PP2A) is a serine/threonine-selective holoenzyme that controls Ca homeostasis and contractility of the heart via dephosphorylation of regulatory proteins. In some genetically modified mouse models with...
5.
Rayo Abella L, Jacob H, Keller M, Schindler L, Pockes S, Pitzl S, et al.
J Pharmacol Exp Ther
. 2024 Mar;
389(2):174-185.
PMID: 38531640
There is a debate on whether H-histamine receptors can alter contractility in the mammalian heart. We studied here a new transgenic mouse model where we increased genetically the cardiac level...
6.
Neumann J, Dhein S, Kirchhefer U, Hofmann B, Gergs U
Front Pharmacol
. 2024 Feb;
15:1334218.
PMID: 38370480
Hallucinogenic drugs are used because they have effects on the central nervous system. Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5-HT-serotonin receptors in the brain. However,...
7.
Neumann J, Dhein S, Kirchhefer U, Hofmann B, Gergs U
Naunyn Schmiedebergs Arch Pharmacol
. 2024 Feb;
397(7):4615-4642.
PMID: 38340182
Central stimulatory and hallucinogenic drugs of abuse like amphetamine and most congeners of amphetamine can have cardiac harmful effects. These cardiac side effects can lead to morbidities and death. In...
8.
Herting J, Konig J, Hadova K, Heinick A, Muller F, Pauls P, et al.
Front Cardiovasc Med
. 2023 Oct;
10:1239555.
PMID: 37868783
Background: The activity, localization, and substrate specificity of the protein phosphatase 2A (PP2A) heterotrimer are controlled by various regulatory B subunits. PR72 belongs to the B'' gene family and has...
9.
Neumann J, Pockes S, Humphrys L, Monnich D, Forster L, Kirchhefer U, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2023 Jul;
397(1):617-626.
PMID: 37490122
Clonidine has various clinical effects mediated by agonism of α- or α-adrenoceptors and the blocking of hyperpolarization-activated-nucleotide-gated pacemaker channels (HCN). It is unknown whether clonidine can also stimulate human cardiac...
10.
Gergs U, Jacob H, Braekow P, Hofmann B, Pockes S, Humphrys L, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2023 Jul;
397(1):221-236.
PMID: 37401967
Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT serotonin receptors and/or H histamine receptors. We studied isolated electrically stimulated left atrial...