Alexander Heinick
Overview
Explore the profile of Alexander Heinick including associated specialties, affiliations and a list of published articles.
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16
Citations
246
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Recent Articles
1.
Herting J, Berg A, Hadova K, Heinick A, Konig S, Kuhlmann M, et al.
J Mol Cell Cardiol Plus
. 2025 Jan;
3():100030.
PMID: 39803363
Protein phosphatase 2A (PP2A) plays a central role in myocardial ischemia-reperfusion (I/R) injury. Several studies showed a detrimental function of PP2A by using either overexpression models of the catalytic subunit...
2.
Herting J, Konig J, Hadova K, Heinick A, Muller F, Pauls P, et al.
Front Cardiovasc Med
. 2023 Oct;
10:1239555.
PMID: 37868783
Background: The activity, localization, and substrate specificity of the protein phosphatase 2A (PP2A) heterotrimer are controlled by various regulatory B subunits. PR72 belongs to the B'' gene family and has...
3.
Glaser D, Heinick A, Herting J, Massing F, Muller F, Pauls P, et al.
J Biol Chem
. 2022 Aug;
298(9):102362.
PMID: 35963431
The activity of protein phosphatase 2A (PP2A) is determined by the expression and localization of the regulatory B-subunits. PP2A-B56α is the dominant isoform of the B'-family in the heart. Its...
4.
Pluteanu F, Boknik P, Heinick A, Konig C, Muller F, Weidlich A, et al.
Am J Physiol Heart Circ Physiol
. 2022 Feb;
322(3):H427-H441.
PMID: 35119335
Protein phosphatase 2A (PP2A) represents a heterotrimer that is responsible for the dephosphorylation of important regulatory myocardial proteins. This study was aimed to test whether the phosphorylation of PP2A-B56α at...
5.
Seidl M, Fels B, Kranick D, Sternberg A, Grimm K, Stumpel F, et al.
FASEB J
. 2020 Jul;
34(8):11272-11291.
PMID: 32602979
ICER (inducible cAMP early repressor) isoforms are transcriptional repressors encoded by the Crem (cAMP responsive element modulator) gene. They were linked to the regulation of a multitude of cellular processes...
6.
Heinick A, Pluteanu F, Hermes C, Klemme A, Domnik M, Husser X, et al.
FASEB J
. 2020 Jun;
34(8):10489-10504.
PMID: 32579290
Adenylyl cyclases (AC) are essential for the normal and pathophysiological response of many cells. In cardiomyocytes, the predominant AC isoforms are AC5 and AC6. Specific AC5 inhibition was suggested as...
7.
Kirchhefer U, Hammer E, Heinick A, Herpertz T, Isensee G, Muller F, et al.
J Mol Cell Cardiol
. 2019 Nov;
143:160.
PMID: 31718792
No abstract available.
8.
Kirchhefer U, Hammer E, Heinick A, Herpertz T, Isensee G, Muller F, et al.
J Mol Cell Cardiol
. 2018 Nov;
125:195-204.
PMID: 30389400
Rationale: A higher expression/activity of type 1 serine/threonine protein phosphatase 1 (PP1) may contribute to dephosphorylation of cardiac regulatory proteins triggering the development of heart failure. Objective: Here, we tested...
9.
Heinick A, Husser X, Himmler K, Kirchhefer U, Nunes F, Schulte J, et al.
FASEB J
. 2015 May;
29(9):3773-87.
PMID: 26023182
Annexin A4 (AnxA4), a Ca(2+)- and phospholipid-binding protein, is up-regulated in the human failing heart. In this study, we examined the impact of AnxA4 on β-adrenoceptor (β-AR)/cAMP-dependent signal transduction. Expression...
10.
Zhang M, Schulte J, Heinick A, Piccini I, Rao J, Quaranta R, et al.
Stem Cells
. 2015 Feb;
33(5):1456-69.
PMID: 25639979
Directed cardiac differentiation of human pluripotent stem cells (hPSCs) enables disease modeling, investigation of human cardiogenesis, as well as large-scale production of cardiomyocytes (CMs) for translational purposes. Multiple CM differentiation...