Francesco Ortuso
Overview
Explore the profile of Francesco Ortuso including associated specialties, affiliations and a list of published articles.
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126
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1452
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Recent Articles
11.
Meleddu R, Corona A, Distinto S, Cottiglia F, Deplano S, Sequeira L, et al.
Molecules
. 2021 Jul;
26(13).
PMID: 34201561
Current therapeutic protocols for the treatment of HIV infection consist of the combination of diverse anti-retroviral drugs in order to reduce the selection of resistant mutants and to allow for...
12.
Costa G, Artese A, Ortuso F, Alcaro S
Methods Mol Biol
. 2021 Mar;
2266:263-277.
PMID: 33759132
Although science and technology have progressed rapidly, de novo drug development has been a costly and time-consuming process over the past decades. In this scenario, drug repurposing has appeared as...
13.
Meleddu R, Deplano S, Maccioni E, Ortuso F, Cottiglia F, Secci D, et al.
J Enzyme Inhib Med Chem
. 2021 Feb;
36(1):685-692.
PMID: 33602041
A small library of coumarin and their psoralen analogues and has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards...
14.
Ortuso F, Mercatelli D, Guzzi P, Giorgi F
J Biomol Struct Dyn
. 2021 Feb;
40(14):6545-6555.
PMID: 33583326
SARS-CoV-2 entry in human cells is mediated by the interaction between the viral Spike protein and the human ACE2 receptor. This mechanism evolved from the ancestor bat coronavirus and is...
15.
Maruca A, Rocca R, Catalano R, Mesiti F, Costa G, Lanzillotta D, et al.
Molecules
. 2020 Dec;
25(23).
PMID: 33255661
Mushrooms can be considered a valuable source of natural bioactive compounds with potential polypharmacological effects due to their proven antimicrobial, antiviral, antitumor, and antioxidant activities. In order to identify new...
16.
Maruca A, Moraca F, Rocca R, Molisani F, Alcaro F, Gidaro M, et al.
Molecules
. 2020 Sep;
22(9).
PMID: 32961649
Mushrooms are widely-consumed fungi which contain natural compounds that can be used both for their nutritive and medicinal properties, i.e., taking advantage of their antimicrobial, antiviral, antitumor, anti-allergic, immunomodulation, anti-inflammatory,...
17.
Volpe S, Listro R, Parafioriti M, Di Giacomo M, Rossi D, Ambrosio F, et al.
ACS Med Chem Lett
. 2020 May;
11(5):883-888.
PMID: 32435400
The Hu family of RNA-binding proteins plays a crucial role in post-transcriptional processes; indeed, Hu-RNA complexes are involved in various dysfunctions (i.e., inflammation, neurodegeneration, and cancer) and have been recently...
18.
Meleddu R, Distinto S, Cottiglia F, Angius R, Caboni P, Angeli A, et al.
ACS Med Chem Lett
. 2020 May;
11(5):852-856.
PMID: 32435395
In the present study we investigated the structure-activity relationships of a new series of 4-[(3-ethyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides (-). All synthesized compounds, with the exception of compound , preferentially inhibit off-target hCA II...
19.
Maruca A, Lanzillotta D, Rocca R, Lupia A, Costa G, Catalano R, et al.
Molecules
. 2020 May;
25(9).
PMID: 32384767
Essential oils (EOs) are popular in aromatherapy, a branch of alternative medicine that claims their curative effects. Moreover, several studies reported EOs as potential anti-cancer agents by inducing apoptosis in...
20.