Florence Borot
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Explore the profile of Florence Borot including associated specialties, affiliations and a list of published articles.
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11
Citations
387
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Recent Articles
1.
Borot F, Humbert O, Newby G, Fields E, Kohli S, Radtke S, et al.
bioRxiv
. 2023 Mar;
PMID: 36865281
Graphical Abstract:
2.
Burke A, Borot F, Du X, Churchill M, Ding J, Grass A, et al.
Oncogene
. 2022 Nov;
42(1):26-34.
PMID: 36357573
Many therapeutic bispecific T-cell engagers (BiTEs) are in clinical trials. A modular and efficient process to create BiTEs would accelerate their development and clinical applicability. In this study, we present...
3.
Galan-Diez M, Borot F, Ali A, Zhao J, Gil-Iturbe E, Shan X, et al.
Cancer Discov
. 2022 Jan;
12(4):1106-1127.
PMID: 35046097
Significance: AML remains recalcitrant to treatments due to the emergence of resistant clones. We show a leukemia-cell nonautonomous progression mechanism that involves activation of a kynurenine-HTR1B-SAA-IDO1 axis between AML cells...
4.
Borot F, Mukherjee S, Ali A
Cancer J
. 2021 Mar;
27(2):143-150.
PMID: 33750074
Myeloid malignancies including myelodysplastic syndromes and acute myeloid leukemia are a group of clonal hematopoietic stem progenitor cell disorders mainly effecting the elderly. Chemotherapeutic approaches improved the outcome in majority...
5.
Borot F, Wang H, Ma Y, Jafarov T, Raza A, Ali A, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(24):11978-11987.
PMID: 31138698
Antigen-directed immunotherapies for acute myeloid leukemia (AML), such as chimeric antigen receptor T cells (CAR-Ts) or antibody-drug conjugates (ADCs), are associated with severe toxicities due to the lack of unique...
6.
Chen X, Deng H, Churchill M, Luchsinger L, Du X, Chu T, et al.
Cell Stem Cell
. 2017 Dec;
21(6):747-760.e7.
PMID: 29198940
Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an...
7.
Veit G, Avramescu R, Perdomo D, Phuan P, Bagdany M, Apaja P, et al.
Sci Transl Med
. 2014 Aug;
6(246):246ra97.
PMID: 25101887
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane regulator (CFTR) that result in reduced anion conductance at the apical membrane of secretory epithelia. Treatment of CF patients...
8.
Borot F, Vieu D, Faure G, Fritsch J, Colas J, Moriceau S, et al.
PLoS One
. 2009 Oct;
4(10):e7116.
PMID: 19847291
The antiinflammatory protein annexin-1 (ANXA1) and the adaptor S100A10 (p11), inhibit cytosolic phospholipase A2 (cPLA2alpha) by direct interaction. Since the latter is responsible for the cleavage of arachidonic acid at...
9.
Dudez T, Borot F, Huang S, Kwak B, Bacchetta M, Ollero M, et al.
Biochim Biophys Acta
. 2008 Feb;
1783(5):779-88.
PMID: 18255040
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause a chronic inflammatory response in the lung of patients with Cystic Fibrosis (CF). We have showed that TNF-alpha signaling through...
10.
Baudouin-Legros M, Hamdaoui N, Borot F, Fritsch J, Ollero M, Planelles G, et al.
Cell Physiol Biochem
. 2008 Jan;
21(1-3):75-86.
PMID: 18209474
The CFTR protein, encoded by the gene whose mutations induce Cystic Fibrosis, is an anion channel devoted mainly to chloride and bicarbonate transmembrane transport, but which also regulates transport of...