Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia

Overview

Journal Cancer Discov

Specialty Oncology

Date 2022 Jan 20

PMID 35046097

Authors

Marta Galan-Diez

Florence Borot

Abdullah Mahmood Ali

Junfei Zhao

Eva Gil-Iturbe

Xiaochuan Shan

Na Luo

Yongfeng Liu

Xi-Ping Huang

Brygida Bisikirska

Rossella Labella

Irwin Kurland

Bryan L Roth

Matthias Quick

Siddhartha Mukherjee

Raul Rabadan

Martin Carroll

Azra Raza

Stavroula Kousteni

Affiliations

Soon will be listed here.

Abstract

Significance: AML remains recalcitrant to treatments due to the emergence of resistant clones. We show a leukemia-cell nonautonomous progression mechanism that involves activation of a kynurenine-HTR1B-SAA-IDO1 axis between AML cells and osteoblasts. Targeting the niche by interrupting this axis can be pharmacologically harnessed to hamper AML progression and overcome therapy resistance. This article is highlighted in the In This Issue feature, p. 873.

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