Fernando Lecanda
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Explore the profile of Fernando Lecanda including associated specialties, affiliations and a list of published articles.
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70
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2323
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Recent Articles
11.
Ruiz-Fernandez de Cordoba B, Moreno H, Valencia K, Perurena N, Ruedas P, Walle T, et al.
Cancer Discov
. 2022 Feb;
12(5):1356-1377.
PMID: 35191482
Abstract: Locoregional failure (LRF) in patients with breast cancer post-surgery and post-irradiation is linked to a dismal prognosis. In a refined new model, we identified ectonucleotide pyrophosphatase/phosphodiesterase 1/CD203a (ENPP1) to...
12.
Ajona D, Ortiz-Espinosa S, Lozano T, Exposito F, Calvo A, Valencia K, et al.
Nat Cancer
. 2022 Feb;
1(1):75-85.
PMID: 35121837
Harnessing the immune system by blocking the programmed cell death protein 1 (PD-1) pathway has been a major breakthrough in non-small-cell lung cancer treatment. Nonetheless, many patients fail to respond...
13.
Ortiz-Espinosa S, Morales X, Senent Y, Alignani D, Tavira B, Macaya I, et al.
Cancer Lett
. 2021 Dec;
529:70-84.
PMID: 34971753
Myeloid-derived suppressor cells (MDSCs) play a major role in cancer progression. In this study, we investigated the mechanisms by which complement C5a increases the capacity of polymorphonuclear MDSCs (PMN-MDSCs) to...
14.
Vallejo A, Erice O, Entrialgo-Cadierno R, Feliu I, Guruceaga E, Perugorria M, et al.
J Hepatol
. 2021 Apr;
75(2):363-376.
PMID: 33887357
Background & Aims: Cholangiocarcinoma (CCA) is a neoplasia of the biliary tract driven by genetic, epigenetic and transcriptional mechanisms. Herein, we investigated the role of the transcription factor FOSL1, as...
15.
Grunewald T, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, et al.
EMBO Mol Med
. 2020 Oct;
12(11):e11131.
PMID: 33047515
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in...
16.
Garcia-Consuegra A, Gimeno Morales M, Cambeiro M, Tagliaferri L, Kovacs G, Van Limbergen E, et al.
Radiother Oncol
. 2020 Sep;
154:128-134.
PMID: 32941955
Background: The Head and Neck and Skin (HNS) Working group of the GEC-ESTRO acknowledges the lack of widely accepted Dose Volume Histogram (DVH) constraints in adjuvant head and neck brachytherapy...
17.
Matsuoka K, Bakiri L, Wolff L, Linder M, Mikels-Vigdal A, Patino-Garcia A, et al.
Cell Res
. 2020 Jul;
30(10):885-901.
PMID: 32686768
Osteosarcoma (OS) is the most frequent primary malignant bone tumor in urgent need of better therapies. Using genetically modified mouse models (GEMMs), we demonstrate that Wnt signaling promotes c-Fos-induced OS...
18.
Rodriguez-Nogales C, Moreno H, Zandueta C, Desmaele D, Lecanda F, Couvreur P, et al.
Cancers (Basel)
. 2020 Jul;
12(7).
PMID: 32674353
Due to chemoresistance and a high propensity to form lung metastasis, survival rates in pediatric osteosarcoma (OS) are poor. With the aim to improve anticancer activity in pediatric OS, a...
19.
Mirabello L, Koster R, Karlins E, Dean M, Yeager M, Gianferante M, et al.
JAMA Oncol
. 2020 Mar;
6(5):724-734.
PMID: 32191290
Importance: Osteosarcoma, the most common malignant bone tumor in children and adolescents, occurs in a high number of cancer predisposition syndromes that are defined by highly penetrant germline mutations. The...
20.
Valencia K, Erice O, Kostyrko K, Hausmann S, Guruceaga E, Tathireddy A, et al.
J Clin Invest
. 2019 Dec;
130(4):1879-1895.
PMID: 31874105
Few therapies are currently available for patients with KRAS-driven cancers, highlighting the need to identify new molecular targets that modulate central downstream effector pathways. Here we found that the microRNA...