Feng-Pai Chou
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Explore the profile of Feng-Pai Chou including associated specialties, affiliations and a list of published articles.
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Citations
379
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Recent Articles
1.
Hue B, Nguyet Huong Giang H, Nguyen C, Chou F, La Duc Thanh D, Tran Q, et al.
RSC Adv
. 2024 Oct;
14(46):33820-33829.
PMID: 39450066
This report presents the design and synthesis of quinazolinone-based derivatives as promising SARS-CoV-2 3CL protease inhibitors. Two novel series, namely, febrifugine analogues 4a-i and quinazolinone conjugated benzimidazoles 9a-c, were successfully...
2.
Liu H, Chou S, Huang S, Huang T, Hsiao P, Chou F, et al.
Chem Biol Drug Des
. 2024 Sep;
104(3):e14624.
PMID: 39317696
In the pentose phosphate pathway, dehydroepiandrosterone (DHEA) uncompetitively inhibits glucose-6-phosphate dehydrogenase (G6PD), reducing NADPH production and increasing oxidative stress, which can influence the onset and/or progression of several diseases, including...
3.
Giang H, Chou F, Chen C, Chou S, Huang S, Wu T, et al.
Viruses
. 2023 Feb;
15(2).
PMID: 36851501
The severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2-M) plays an essential role in viral replication, transcription, maturation, and entry into host cells. Furthermore, its cleavage specificity for viruses,...
4.
Chou F, Liu C, Nguyet Huong Giang H, Huang S, Hsu H, Wu T
Heliyon
. 2022 Mar;
8(3):e09034.
PMID: 35252620
The main protease (M) of SARS-CoV-2 is a protease necessary for viral polyprotein processing and maturation. M cleaves the polypeptide sequence after the glutamine residues. There is no known cellular...
5.
Chou F, Hsu W, Huang S, Chang C, Chiou Y, Tsai C, et al.
Chem Commun (Camb)
. 2020 Jan;
56(11):1733-1736.
PMID: 31938799
We report here that pregnenolonyl-α-glucoside (2), a steryl glycoside synthesized directly from pregnenolone and glucose via a consecutive multienzyme-catalyzed process, exhibits marked dose-dependent cytotoxic activity against HT29, AGS, and ES-2...
6.
Wang Y, Huang S, Chang C, Huang W, Liao M, Yip B, et al.
Sci Rep
. 2019 Jul;
9(1):9833.
PMID: 31285470
Oligomerization of protein into specific quaternary structures plays important biological functions, including regulation of gene expression, enzymes activity, and cell-cell interactions. Here, we report the determination of two crystal structures...
7.
Chen W, Chou F, Wang Y, Huang S, Cheng C, Wu T
Virol J
. 2017 Oct;
14(1):189.
PMID: 28969658
Background: Dengue virus (DV) infection causes a spectrum of clinical diseases ranging from dengue fever to a life-threatening dengue hemorrhagic fever. Four distinct serotypes (DV1-4), which have similar genome sequences...
8.
Chou F, Tsai C, Chiou Y, Chen Y, Li M, Guo T, et al.
Chem Biol Drug Des
. 2016 Sep;
89(1):61-66.
PMID: 27647631
Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell...
9.
Lai C, Lai Y, Chou F, Chang H, Tseng C, Johnson M, et al.
PLoS One
. 2016 Apr;
11(4):e0152904.
PMID: 27043831
Significant proteolysis may occur during milk synthesis and secretion, as evidenced by the presence of protease-protease inhibitor complex containing the activated form of the type 2 transmembrane serine protease matriptase...
10.
Chou F, Chen Y, Zhao X, Xu-Monette Z, Young K, Gartenhaus R, et al.
Am J Pathol
. 2013 Sep;
183(4):1306-17.
PMID: 24070417
Membrane-associated serine protease matriptase is widely expressed by epithelial/carcinoma cells in which its proteolytic activity is tightly controlled by the Kunitz-type protease inhibitor, hepatocyte growth factor activator inhibitor (HAI-1). We...