I-Chu Tseng
Overview
Explore the profile of I-Chu Tseng including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
462
Followers
0
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Recent Articles
1.
Zhao Y, Tseng I, Heyser C, Rockenstein E, Mante M, Adame A, et al.
Neuron
. 2024 Nov;
112(23):3984-3985.
PMID: 39520984
No abstract available.
2.
Tseng C, Jia B, Barndt R, Gu Y, Chen C, Tseng I, et al.
PLoS One
. 2017 Aug;
12(8):e0183507.
PMID: 28829816
The type 2 transmembrane serine protease matriptase is involved in many pathophysiological processes probably via its enzymatic activity, which depends on the dynamic relationship between zymogen activation and protease inhibition....
3.
Wang X, Zhou Y, Wang J, Tseng I, Huang T, Zhao Y, et al.
J Neurosci
. 2016 Dec;
36(50):12586-12597.
PMID: 27974614
Significance Statement: Down's syndrome (DS) in humans and mouse models has been shown previously to confer a high risk for the development of pathological hydrocephalus. Because we have previously described...
4.
Huang T, Zhao Y, Li X, Wang X, Tseng I, Thompson R, et al.
J Neurosci
. 2016 Jul;
36(30):7996-8011.
PMID: 27466343
Unlabelled: Proteolytic generation of amyloidogenic amyloid β (Aβ) fragments from the amyloid precursor protein (APP) significantly contributes to Alzheimer's disease (AD). Although amyloidogenic APP proteolysis can be affected by trafficking...
5.
Zhao Y, Tseng I, Heyser C, Rockenstein E, Mante M, Adame A, et al.
Neuron
. 2015 Sep;
87(5):963-75.
PMID: 26335643
Progressive supranuclear palsy (PSP) is a movement disorder characterized by tau neuropathology where the underlying mechanism is unknown. An SNP (rs1768208 C/T) has been identified as a strong risk factor...
6.
Wang J, Teng I, Lo T, Moore S, Yeo Y, Teng Y, et al.
PLoS One
. 2014 Apr;
9(4):e93899.
PMID: 24705933
The ability of cells to rapidly detect and react to alterations in their chemical environment, such as pH, ionic strength and redox potential, is essential for cell function and survival....
7.
Justilien V, Regala R, Tseng I, Walsh M, Batra J, Radisky E, et al.
PLoS One
. 2012 May;
7(4):e35040.
PMID: 22545096
Matrix metalloproteinases (Mmps) stimulate tumor invasion and metastasis by degrading the extracellular matrix. Here we reveal an unexpected role for Mmp10 (stromelysin 2) in the maintenance and tumorigenicity of mouse...
8.
Xu H, Xu Z, Tseng I, Chou F, Chen Y, Wang J, et al.
Am J Physiol Cell Physiol
. 2011 Oct;
302(2):C453-62.
PMID: 22031598
Matriptase proteolytic activity must be tightly controlled for normal placental development, epidermal function, and epithelial integrity. Although hepatocyte growth factor activator inhibitor-1 (HAI-1) represents the predominant endogenous inhibitor for matriptase...
9.
Tseng I, Xu H, Chou F, Li G, Vazzano A, Kao J, et al.
J Biol Chem
. 2009 Nov;
285(5):3261-70.
PMID: 19940125
Extracellular acidosis often rapidly causes intracellular acidification, alters ion channel activities, and activates G protein-coupled receptors. In this report, we demonstrated a novel cellular response to acidosis: induction of the...
10.
Wang J, Lee M, Tseng I, Chou F, Chen Y, Fulton A, et al.
Am J Physiol Cell Physiol
. 2009 Jun;
297(2):C459-70.
PMID: 19535514
Matriptase, a transmembrane serine protease, is broadly expressed by, and crucial for the integrity of, the epithelium. Matriptase is synthesized as a zymogen and undergoes autoactivation to become an active...