Felix Naef
Overview
Explore the profile of Felix Naef including associated specialties, affiliations and a list of published articles.
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104
Citations
5269
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Recent Articles
1.
Phillips N, Mareschal J, Biancolin A, Sinturel F, Umwali S, Blanc S, et al.
Diabetologia
. 2024 Nov;
68(2):419-432.
PMID: 39531039
Aims/hypothesis: Gestational diabetes mellitus (GDM) affects 14% of all pregnancies worldwide and is associated with cardiometabolic risk. We aimed to exploit high-resolution wearable device time-series data to create a fine-grained...
2.
Lederer A, Leonardi M, Talamanca L, Bobrovskiy D, Herrera A, Droin C, et al.
Nat Methods
. 2024 Nov;
21(12):2271-2286.
PMID: 39482463
Across biological systems, cells undergo coordinated changes in gene expression, resulting in transcriptome dynamics that unfold within a low-dimensional manifold. While low-dimensional dynamics can be extracted using RNA velocity, these...
3.
Martini T, Gobet C, Salati A, Blanc J, Mookhoek A, Reinehr M, et al.
Nat Commun
. 2024 Sep;
15(1):8422.
PMID: 39341814
Recent single-cell transcriptomes revealed spatiotemporal programmes of liver function on the sublobular scale. However, how sexual dimorphism affected this space-time logic remained poorly understood. We addressed this by performing scRNA-seq...
4.
Lederer A, Leonardi M, Talamanca L, Herrera A, Droin C, Khven I, et al.
bioRxiv
. 2024 Feb;
PMID: 38328127
Across a range of biological processes, cells undergo coordinated changes in gene expression, resulting in transcriptome dynamics that unfold within a low-dimensional manifold. Single-cell RNA-sequencing (scRNA-seq) only measures temporal snapshots...
5.
Phillips N, Collet T, Naef F
Cell Rep Methods
. 2023 Sep;
3(8):100545.
PMID: 37671030
Wearable biosensors and smartphone applications can measure physiological variables over multiple days in free-living conditions. We measure food and drink ingestion, glucose dynamics, physical activity, heart rate (HR), and heart...
6.
Talamanca L, Gobet C, Naef F
Science
. 2023 Feb;
379(6631):478-483.
PMID: 36730411
The circadian clock modulates human physiology. However, the organization of tissue-specific gene expression rhythms and how these depend on age and sex is not defined in humans. We combined data...
7.
Martini T, Naef F, Tchorz J
Annu Rev Pathol
. 2023 Jan;
18:439-466.
PMID: 36693201
Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis. Division of labor between hepatocytes...
8.
Li T, Gao A, Li X, Li H, Liu Y, Lalou A, et al.
J Cell Biol
. 2022 Oct;
222(1).
PMID: 36314986
To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial...
9.
Hurni C, Weger B, Gobet C, Naef F
PLoS Genet
. 2022 Aug;
18(8):e1009903.
PMID: 35921362
In eukaryotes, RNA is synthesised in the nucleus, spliced, and exported to the cytoplasm where it is translated and finally degraded. Any of these steps could be subject to temporal...
10.
Gobet C, Naef F
Methods
. 2021 Oct;
203:10-16.
PMID: 34673173
Protein synthesis is an energy consuming process characterised as a pivotal and highly regulated step in gene expression. The net protein output is dictated by a combination of translation initiation,...