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Damien Nicolas

Explore the profile of Damien Nicolas including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 353
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Recent Articles
1.
Phillips N, Hugues A, Yeung J, Durandau E, Nicolas D, Naef F
Mol Syst Biol . 2021 Mar; 17(3):e10135. PMID: 33719202
The circadian clock is an endogenous and self-sustained oscillator that anticipates daily environmental cycles. While rhythmic gene expression of circadian genes is well-described in populations of cells, the single-cell mRNA...
2.
Krishnan A, Kloehn J, Lunghi M, Chiappino-Pepe A, Waldman B, Nicolas D, et al.
Cell Host Microbe . 2020 Jan; 27(2):290-306.e11. PMID: 31991093
To survive and proliferate in diverse host environments with varying nutrient availability, the obligate intracellular parasite Toxoplasma gondii reprograms its metabolism. We have generated and curated a genome-scale metabolic model...
3.
Nicolas D, Zoller B, Suter D, Naef F
Proc Natl Acad Sci U S A . 2018 Jun; 115(27):7153-7158. PMID: 29915087
Many mammalian genes are transcribed during short bursts of variable frequencies and sizes that substantially contribute to cell-to-cell variability. However, which molecular mechanisms determine bursting properties remains unclear. To probe...
4.
Mermet J, Yeung J, Hurni C, Mauvoisin D, Gustafson K, Jouffe C, et al.
Genes Dev . 2018 Mar; 32(5-6):347-358. PMID: 29572261
The circadian clock in animals orchestrates widespread oscillatory gene expression programs, which underlie 24-h rhythms in behavior and physiology. Several studies have shown the possible roles of transcription factors and...
5.
Nicolas D, Phillips N, Naef F
Mol Biosyst . 2017 Jun; 13(7):1280-1290. PMID: 28573295
Isogenic cells in a common environment present a large degree of heterogeneity in gene expression. Part of this variability is attributed to transcriptional bursting: the stochastic activation and inactivation of...
6.
Zoller B, Nicolas D, Molina N, Naef F
Mol Syst Biol . 2015 Jul; 11(7):823. PMID: 26215071
Mammalian transcription occurs stochastically in short bursts interspersed by silent intervals showing a refractory period. However, the underlying processes and consequences on fluctuations in gene products are poorly understood. Here,...
7.
Blanchoud S, Nicolas D, Zoller B, Tidin O, Naef F
Methods . 2015 May; 85:3-11. PMID: 25934263
Fluorescence and bioluminescence time-lapse imaging allows to investigate a vast range of cellular processes at single-cell or even subcellular resolution. In particular, time-lapse imaging can provide uniquely detailed information on...
8.
Miyazaki R, Bertelli C, Benaglio P, Canton J, De Coi N, Gharib W, et al.
Environ Microbiol . 2014 May; 17(1):91-104. PMID: 24803113
Pseudomonas knackmussii B13 was the first strain to be isolated in 1974 that could degrade chlorinated aromatic hydrocarbons. This discovery was the prologue for subsequent characterization of numerous bacterial metabolic...