Fayyaz S Sutterwala
Overview
Explore the profile of Fayyaz S Sutterwala including associated specialties, affiliations and a list of published articles.
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101
Citations
9008
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Recent Articles
1.
Gupta S, Cassel S, Sutterwala F, Dagvadorj J
Immunol Rev
. 2024 Oct;
329(1):e13410.
PMID: 39417249
The NLRP3 inflammasome is a multiprotein complex that upon activation by the innate immune system drives a broad inflammatory response. The primary initial mediators of this response are pro-IL-1β and...
2.
Leung J, Chang M, Moore R, Dagvadorj J, Sutterwala F, Cassel S
Immunohorizons
. 2024 Sep;
8(9):679-687.
PMID: 39264735
Silica crystals activate the NLRP3 inflammasome in macrophages, resulting in the caspase-1-dependent secretion of the proinflammatory cytokine IL-1β. Caspase-1-mediated cleavage of gasdermin D (GSDMD) triggers the formation of GSDMD pores,...
3.
Sanches Santos Rizzo Zuttion M, Parimon T, Bora S, Yao C, Lagree K, Gao C, et al.
J Clin Invest
. 2024 Sep;
134(21).
PMID: 39255040
A leading cause of mortality after influenza infection is the development of a secondary bacterial pneumonia. In the absence of a bacterial superinfection, prescribing antibacterial therapies is not indicated but...
4.
Gupta S, Cassel S, Sutterwala F
Methods Mol Biol
. 2023 Aug;
2696:29-45.
PMID: 37578713
Pattern recognition receptors, including members of the NLR and ALR families, are essential for recognition of both pathogen- and host-derived danger signals. Several members of these families, including NLRP1, NLRP3,...
5.
Sawaged S, Mota T, Piplani H, Thakur R, Lall D, McCabe E, et al.
PLoS Pathog
. 2022 Aug;
18(8):e1010350.
PMID: 36044516
Host-pathogen dynamics are constantly at play during enteroviral infection. Coxsackievirus B (CVB) is a common juvenile enterovirus that infects multiple organs and drives inflammatory diseases including acute pancreatitis and myocarditis....
6.
Hardy K, Tuckey A, Housley N, Andrews J, Patel M, Al-Mehdi A, et al.
Infect Immun
. 2022 Feb;
90(3):e0047021.
PMID: 35130452
Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P. aeruginosa pathogenesis is disruption of host cell function by the...
7.
Ernst O, Sun J, Lin B, Banoth B, Dorrington M, Liang J, et al.
Sci Signal
. 2021 Aug;
14(694).
PMID: 34344832
Noncanonical inflammasome activation by cytosolic lipopolysaccharide (LPS) is a critical component of the host response to Gram-negative bacteria. Cytosolic LPS recognition in macrophages is preceded by a Toll-like receptor (TLR)...
8.
Dagvadorj J, Mikulska-Ruminska K, Tumurkhuu G, Ratsimandresy R, Carriere J, Andres A, et al.
Proc Natl Acad Sci U S A
. 2020 Dec;
118(1).
PMID: 33361152
The balance between NLRP3 inflammasome activation and mitophagy is essential for homeostasis and cellular health, but this relationship remains poorly understood. Here we found that interleukin-1α (IL-1α)-deficient macrophages have reduced...
9.
Borbon T, Scorza B, Clay G, Lima Nobre de Queiroz F, Sariol A, Bowen J, et al.
PLoS Negl Trop Dis
. 2019 May;
13(5):e0007247.
PMID: 31107882
Cutaneous leishmaniasis (CL) is a parasitic disease causing chronic, ulcerating skin lesions. Most humans infected with the causative Leishmania protozoa are asymptomatic. Leishmania spp. are usually introduced by sand flies...
10.
Ohashi K, Wang Z, Yang Y, Billet S, Tu W, Pimienta M, et al.
Hepatology
. 2019 May;
70(5):1582-1599.
PMID: 31044438
Nonalcoholic fatty liver disease (NAFLD) enhances the growth and recurrence of colorectal cancer (CRC) liver metastasis. With the rising prevalence of NAFLD, a better understanding of the molecular mechanism underlying...