Klaus Mohr
Overview
Explore the profile of Klaus Mohr including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
67
Citations
1163
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Holze J, Bermudez M, Pfeil E, Kauk M, Bodefeld T, Irmen M, et al.
ACS Pharmacol Transl Sci
. 2020 Oct;
3(5):859-867.
PMID: 33073186
Allosteric coupling describes a reciprocal process whereby G-protein-coupled receptors (GPCRs) relay ligand-induced conformational changes from the extracellular binding pocket to the intracellular signaling surface. Therefore, GPCR activation is sensitive to...
2.
Matucci R, Bellucci C, Martino M, Nesi M, Manetti D, Welzel J, et al.
Eur J Pharmacol
. 2020 Jun;
883:173183.
PMID: 32534072
Although agonists and antagonists of muscarinic receptors have been known for long time, there is renewed interest in compounds (such as allosteric or bitopic ligands, or biased agonists) able to...
3.
Etscheid J, Mohr K, Schlicker E
Naunyn Schmiedebergs Arch Pharmacol
. 2018 Jul;
391(11):1295-1299.
PMID: 30032313
Muscarinic M and M receptors resemble each other in brain distribution, function, and G protein signaling. However, there is evidence from human recombinant receptors that the M receptor also couples...
4.
Merten N, Fischer J, Simon K, Zhang L, Schroder R, Peters L, et al.
Cell Chem Biol
. 2018 May;
25(6):775-786.e5.
PMID: 29706593
Identification of additional uses for existing drugs is a hot topic in drug discovery and a viable alternative to de novo drug development. HAMI3379 is known as an antagonist of...
5.
Bock A, Schrage R, Mohr K
Neuropharmacology
. 2017 Sep;
136(Pt C):427-437.
PMID: 28935216
Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) which are broadly expressed in the central nervous system (CNS) and other tissues in the periphery. They emerge as important drug targets...
6.
Bermudez M, Bock A, Krebs F, Holzgrabe U, Mohr K, Lohse M, et al.
ACS Chem Biol
. 2017 Jun;
12(7):1743-1748.
PMID: 28585805
G protein-coupled receptors transmit extracellular signals across cell membranes via different G protein classes and β-arrestins. Some pathways may be therapeutically beneficial, whereas others may be detrimental under certain pathophysiological...
7.
Simon K, Merten N, Schroder R, Hennen S, Preis P, Schmitt N, et al.
Mol Pharmacol
. 2017 Mar;
91(5):518-532.
PMID: 28254957
Pairing orphan G protein–coupled receptors (GPCRs) with their cognate endogenous ligands is expected to have a major impact on our understanding of GPCR biology. It follows that the reproducibility of...
8.
De Min A, Matera C, Bock A, Holze J, Kloeckner J, Muth M, et al.
Mol Pharmacol
. 2017 Feb;
91(4):348-356.
PMID: 28167741
Protean agonists are of great pharmacological interest as their behavior may change in magnitude and direction depending on the constitutive activity of a receptor. Yet, this intriguing phenomenon has been...
9.
Seemann W, Wenzel D, Schrage R, Etscheid J, Bodefeld T, Bartol A, et al.
J Pharmacol Exp Ther
. 2017 Jan;
360(2):289-299.
PMID: 28082514
Drug discovery strives for selective ligands to achieve targeted modulation of tissue function. Here we introduce engineered context-sensitive agonism as a postreceptor mechanism for tissue-selective drug action through a G...
10.
Bock A, Bermudez M, Krebs F, Matera C, Chirinda B, Sydow D, et al.
J Biol Chem
. 2016 Jun;
291(31):16375-89.
PMID: 27298318
G protein-coupled receptors constitute the largest family of membrane receptors and modulate almost every physiological process in humans. Binding of agonists to G protein-coupled receptors induces a shift from inactive...