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Eva Gomez-Orte

Explore the profile of Eva Gomez-Orte including associated specialties, affiliations and a list of published articles. Areas
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Articles 21
Citations 306
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Recent Articles
1.
Romero-Aranda C, Saenz-Narciso B, Gomez-Orte E, Metola A, Ezcurra B, Calvo O, et al.
MicroPubl Biol . 2024 Nov; 2024. PMID: 39575199
The Integrator complex is a set of at least 13 evolutionarily conserved proteins that binds the C-terminal domain of RNA polymerase II to regulate snRNA 3'-end processing and gene expression....
2.
Colino-Lage H, Guerrero-Gomez D, Gomez-Orte E, Gonzalez X, Martina J, Dansen T, et al.
Free Radic Biol Med . 2024 Jul; 223:369-383. PMID: 39059513
Basic Helix-Loop-Helix (bHLH) transcription factors TFEB/TFE3 and HLH-30 are key regulators of autophagy induction and lysosomal biogenesis in mammals and C. elegans, respectively. While much is known about the regulation...
3.
Escrich V, Romero-Aranda C, Lopez R, de Toro M, Metola A, Ezcurra B, et al.
Cancers (Basel) . 2024 Jul; 16(13). PMID: 39001402
The human Integrator complex is a set of 15 subunits that mediates processing of small nuclear RNAs (snRNAs), and which later participates in splicing messenger RNAs (mRNAs). In addition, it...
4.
Blanco-Luquin I, Acha B, Urdanoz-Casado A, Gomez-Orte E, Roldan M, Perez-Rodriguez D, et al.
Cells . 2022 Apr; 11(7). PMID: 35406633
In view of the proven link between adult hippocampal neurogenesis (AHN) and learning and memory impairment, we generated a straightforward adult neurogenesis model to recapitulate DNA methylation marks in the...
5.
Garcia-Casas P, Alvarez-Illera P, Gomez-Orte E, Cabello J, Fonteriz R, Montero M, et al.
Front Pharmacol . 2021 Jul; 12:695687. PMID: 34211399
We have reported recently that the mitochondrial Na/Ca exchanger inhibitor CGP37157 extends lifespan in by a mechanism involving mitochondria, the TOR pathway and the insulin/IGF1 pathway. Here we show that...
6.
Martina J, Guerrero-Gomez D, Gomez-Orte E, Barcena J, Cabello J, Miranda-Vizuete A, et al.
EMBO J . 2020 Dec; 40(3):e105793. PMID: 33314217
Mammalian TFEB and TFE3, as well as their ortholog in Caenorhabditis elegans HLH-30, play an important role in mediating cellular response to a variety of stress conditions, including nutrient deprivation,...
7.
Escrich V, Ezcurra B, Gomez-Orte E, Romero-Aranda C, Miranda-Vizuete A, Cabello J
J Vis Exp . 2020 Oct; (164). PMID: 33104066
4D microscopy is an invaluable tool for unraveling the embryonic developmental process in different animals. Over the last decades, Caenorhabditis elegans has emerged as one of the best models for...
8.
Zheleva A, Gomez-Orte E, Saenz-Narciso B, Ezcurra B, Kassahun H, de Toro M, et al.
PLoS Genet . 2019 Sep; 15(9):e1008338. PMID: 31525188
Animal development requires the execution of specific transcriptional programs in different sets of cells to build tissues and functional organs. Transcripts are exported from the nucleus to the cytoplasm where...
9.
Gomez-Orte E, Saenz-Narciso B, Zheleva A, Ezcurra B, de Toro M, Lopez R, et al.
PLoS Genet . 2019 Feb; 15(2):e1007981. PMID: 30807579
Gene expression is generally regulated by recruitment of transcription factors and RNA polymerase II (RNAP II) to specific sequences in the gene promoter region. The Integrator complex mediates processing of...
10.
Navo C, Asin A, Gomez-Orte E, Gutierrez-Jimenez M, Companon I, Ezcurra B, et al.
Chemistry . 2018 Apr; 24(31):7991-8000. PMID: 29603441
A series of fluorescent d-cysteines (Cys) has been synthesized and their optical properties were studied. The key synthetic step is the highly diastereoselective 1,4-conjugate addition of aryl thiols to a...