Begona Ezcurra
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Explore the profile of Begona Ezcurra including associated specialties, affiliations and a list of published articles.
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9
Citations
64
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Recent Articles
1.
Romero-Aranda C, Saenz-Narciso B, Gomez-Orte E, Metola A, Ezcurra B, Calvo O, et al.
MicroPubl Biol
. 2024 Nov;
2024.
PMID: 39575199
The Integrator complex is a set of at least 13 evolutionarily conserved proteins that binds the C-terminal domain of RNA polymerase II to regulate snRNA 3'-end processing and gene expression....
2.
Guijarro-Hernandez A, Hurtado C, Urizar-Compains E, Ezcurra B, Galiana-Saenz A, Baquero E, et al.
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39519157
In previous research, we created a model with homozygous mutations in calreticulin similar to those found in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF), two myeloproliferative neoplasms (MPNs)....
3.
Escrich V, Romero-Aranda C, Lopez R, de Toro M, Metola A, Ezcurra B, et al.
Cancers (Basel)
. 2024 Jul;
16(13).
PMID: 39001402
The human Integrator complex is a set of 15 subunits that mediates processing of small nuclear RNAs (snRNAs), and which later participates in splicing messenger RNAs (mRNAs). In addition, it...
4.
Guijarro-Hernandez A, Eder-Azanza L, Hurtado C, Navarro-Herrera D, Ezcurra B, Novo F, et al.
Cells
. 2023 Jan;
12(1).
PMID: 36611979
There is growing evidence that -negative myeloproliferative neoplasms (MPNs) are disorders in which multiple molecular mechanisms are significantly disturbed. Since their discovery, driver mutations have been demonstrated to trigger pathogenic...
5.
Escrich V, Ezcurra B, Gomez-Orte E, Romero-Aranda C, Miranda-Vizuete A, Cabello J
J Vis Exp
. 2020 Oct;
(164).
PMID: 33104066
4D microscopy is an invaluable tool for unraveling the embryonic developmental process in different animals. Over the last decades, Caenorhabditis elegans has emerged as one of the best models for...
6.
Zheleva A, Gomez-Orte E, Saenz-Narciso B, Ezcurra B, Kassahun H, de Toro M, et al.
PLoS Genet
. 2019 Sep;
15(9):e1008338.
PMID: 31525188
Animal development requires the execution of specific transcriptional programs in different sets of cells to build tissues and functional organs. Transcripts are exported from the nucleus to the cytoplasm where...
7.
Gomez-Orte E, Saenz-Narciso B, Zheleva A, Ezcurra B, de Toro M, Lopez R, et al.
PLoS Genet
. 2019 Feb;
15(2):e1007981.
PMID: 30807579
Gene expression is generally regulated by recruitment of transcription factors and RNA polymerase II (RNAP II) to specific sequences in the gene promoter region. The Integrator complex mediates processing of...
8.
Navo C, Asin A, Gomez-Orte E, Gutierrez-Jimenez M, Companon I, Ezcurra B, et al.
Chemistry
. 2018 Apr;
24(31):7991-8000.
PMID: 29603441
A series of fluorescent d-cysteines (Cys) has been synthesized and their optical properties were studied. The key synthetic step is the highly diastereoselective 1,4-conjugate addition of aryl thiols to a...
9.
Gomez-Orte E, Cornes E, Zheleva A, Saenz-Narciso B, de Toro M, Iniguez M, et al.
Oncotarget
. 2018 Mar;
9(11):9556-9571.
PMID: 29515753
The transcriptomes of model organisms have been defined under specific laboratory growth conditions. The standard protocol for growth and maintenance is 20°C on an diet. Temperatures ranging from 15°C to...