Integrator Complex Subunit 6 (INTS-6) Mediates DNA Damage Response in

Overview

Journal MicroPubl Biol

Specialty Biology

Date 2024 Nov 22

PMID 39575199

Authors

Cristina Romero-Aranda

Beatriz Saenz-Narciso

Eva Gomez-Orte

Angela Metola

Begona Ezcurra

Olga Calvo

Hilde Nilsen

Antonio Miranda-Vizuete

Juan Cabello

Affiliations

Soon will be listed here.

Abstract

The Integrator complex is a set of at least 13 evolutionarily conserved proteins that binds the C-terminal domain of RNA polymerase II to regulate snRNA 3'-end processing and gene expression. Here we show that the Integrator subunit 6 intervenes in the DNA damage response in . We find that upon X-ray radiation, INTS-6 is necessary for RAD-51 foci formation. In addition, CDK-1 Tyr-15 phosphorylation depends on the presence of INTS-6 . This work adds a new piece to elucidate the Integrator complex mechanism of action in DNA repair.

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