Euan Gordon
Overview
Explore the profile of Euan Gordon including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
146
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0
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Recent Articles
1.
Oster L, Castaldo M, de Vries E, Edfeldt F, Pemberton N, Gordon E, et al.
J Biol Chem
. 2024 Mar;
300(5):107201.
PMID: 38508313
The salt-inducible kinases (SIKs) 1 to 3, belonging to the AMPK-related kinase family, serve as master regulators orchestrating a diverse set of physiological processes such as metabolism, bone formation, immune...
2.
Narjes F, Edfeldt F, Petersen J, Oster L, Hamblet C, Bird J, et al.
J Med Chem
. 2024 Jan;
67(3):2220-2235.
PMID: 38284169
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived pro-inflammatory cytokine involved in the development of asthma and other atopic diseases. We used Bicycle Therapeutics' proprietary phage display platform to identify bicyclic...
3.
Fletcher A, Clift D, de Vries E, Martinez Cuesta S, Malcolm T, Meghini F, et al.
Nat Commun
. 2023 Nov;
14(1):7093.
PMID: 37925433
Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor patient prognosis, implicating it...
4.
Ivanova A, Badertscher L, ODriscoll G, Bergman J, Gordon E, Gunnarsson A, et al.
Adv Sci (Weinh)
. 2023 Oct;
10(34):e2304389.
PMID: 37867228
Efficient and targeted delivery of therapeutic agents remains a bottleneck in modern medicine. Here, biochemical engineering approaches to advance the repurposing of extracellular vesicles (EVs) as drug delivery vehicles are...
5.
Bestas B, Wimberger S, Degtev D, Madsen A, Rottner A, Karlsson F, et al.
Nat Commun
. 2023 Sep;
14(1):5474.
PMID: 37673883
Streptococcus pyogenes Cas9 (SpCas9) and derived enzymes are widely used as genome editors, but their promiscuous nuclease activity often induces undesired mutations and chromosomal rearrangements. Several strategies for mapping off-target...
6.
Postel S, Wissler L, Johansson C, Gunnarsson A, Gordon E, Collins B, et al.
Nat Struct Mol Biol
. 2023 Feb;
30(3):286-295.
PMID: 36747092
The glucocorticoid receptor (GR) is a ligand-activated transcription factor that binds DNA and assembles co-regulator complexes to regulate gene transcription. GR agonists are widely prescribed to people with inflammatory and...
7.
Gutgsell A, Gunnarsson A, Forssen P, Gordon E, Fornstedt T, Geschwindner S
Anal Chem
. 2021 Dec;
94(2):1187-1194.
PMID: 34964599
Avidity is an effective and frequent phenomenon employed by nature to achieve extremely high-affinity interactions. As more drug discovery efforts aim to disrupt protein-protein interactions, it is becoming increasingly common...
8.
Li S, Akrap N, Cerboni S, Porritt M, Wimberger S, Lundin A, et al.
Nat Commun
. 2021 May;
12(1):2832.
PMID: 33972550
No abstract available.
9.
Li S, Akrap N, Cerboni S, Porritt M, Wimberger S, Lundin A, et al.
Nat Commun
. 2021 Jan;
12(1):497.
PMID: 33479216
Prokaryotic restriction enzymes, recombinases and Cas proteins are powerful DNA engineering and genome editing tools. However, in many primary cell types, the efficiency of genome editing remains low, impeding the ...
10.
Munck Af Rosenschold M, Johannesson P, Nikitidis A, Tyrchan C, Chang H, Ronn R, et al.
J Med Chem
. 2019 Aug;
62(17):7769-7787.
PMID: 31415176
While bronchodilators and inhaled corticosteroids are the mainstay of asthma treatment, up to 50% of asthmatics remain uncontrolled. Many studies show that the cysteinyl leukotriene cascade remains highly activated in...