Mohammad Bohlooly-Y
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Explore the profile of Mohammad Bohlooly-Y including associated specialties, affiliations and a list of published articles.
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80
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6210
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Recent Articles
1.
Payandeh Z, Tangruksa B, Synnergren J, Heydarkhan-Hagvall S, Nordin J, El Andaloussi S, et al.
Mol Aspects Med
. 2024 Aug;
99:101302.
PMID: 39094449
Modern methods of molecular diagnostics and therapy have revolutionized the field of medicine in recent years by providing more precise and effective tools for detecting and treating diseases. This progress...
2.
Ruiz M, Devkota R, Bergh P, Nik A, Blid Skoldheden S, Mondejar-Duran J, et al.
FASEB J
. 2024 Jul;
38(14):e23815.
PMID: 38989587
To investigate how the fatty acid composition of brain phospholipids influences brain-specific processes, we leveraged the AdipoR2 (adiponectin receptor 2) knockout mouse model in which the brain is enlarged, and...
3.
Zhang J, Ruiz M, Bergh P, Henricsson M, Stojanovic N, Devkota R, et al.
Nat Commun
. 2024 Mar;
15(1):2315.
PMID: 38485951
The cellular membrane in male meiotic germ cells contains a unique class of phospholipids and sphingolipids that is required for male reproduction. Here, we show that a conserved membrane fluidity...
4.
Bestas B, Wimberger S, Degtev D, Madsen A, Rottner A, Karlsson F, et al.
Nat Commun
. 2023 Sep;
14(1):5474.
PMID: 37673883
Streptococcus pyogenes Cas9 (SpCas9) and derived enzymes are widely used as genome editors, but their promiscuous nuclease activity often induces undesired mutations and chromosomal rearrangements. Several strategies for mapping off-target...
5.
Wimberger S, Akrap N, Firth M, Brengdahl J, Engberg S, Schwinn M, et al.
Nat Commun
. 2023 Aug;
14(1):4761.
PMID: 37580318
Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of unintended mutations...
6.
Palmgren H, Petkevicius K, Bartesaghi S, Ahnmark A, Ruiz M, Nilsson R, et al.
Diabetes
. 2022 Dec;
72(10):1350-1363.
PMID: 36580483
Increased saturated fatty acid (SFA) levels in membrane phospholipids have been implicated in the development of metabolic disease. Here, we tested the hypothesis that increased SFA content in cell membranes...
7.
Ruiz M, Devkota R, Panagaki D, Bergh P, Kaper D, Henricsson M, et al.
Nat Commun
. 2022 Nov;
13(1):7162.
PMID: 36418331
Cells and organisms require proper membrane composition to function and develop. Phospholipids are the major component of membranes and are primarily acquired through the diet. Given great variability in diet...
8.
Buvall L, Menzies R, Williams J, Woollard K, Kumar C, Granqvist A, et al.
Front Pharmacol
. 2022 Nov;
13:971065.
PMID: 36408217
Kidney disease is a complex disease with several different etiologies and underlying associated pathophysiology. This is reflected by the lack of effective treatment therapies in chronic kidney disease (CKD) that...
9.
Nag A, Dhindsa R, Mitchell J, Vasavda C, Harper A, Vitsios D, et al.
Sci Adv
. 2022 Nov;
8(46):eadd5430.
PMID: 36383675
We performed collapsing analyses on 454,796 UK Biobank (UKB) exomes to detect gene-level associations with diabetes. Recessive carriers of nonsynonymous variants in were 30% less likely to develop diabetes (...
10.
Petkevicius K, Palmgren H, Glover M, Ahnmark A, Andreasson A, Madeyski-Bengtson K, et al.
Nat Commun
. 2022 Oct;
13(1):6020.
PMID: 36241646
The fatty acid composition of phosphatidylethanolamine (PE) determines cellular metabolism, oxidative stress, and inflammation. However, our understanding of how cells regulate PE composition is limited. Here, we identify a genetic...