Sandra Wimberger
Overview
Explore the profile of Sandra Wimberger including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
136
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0
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Recent Articles
1.
Bestas B, Wimberger S, Degtev D, Madsen A, Rottner A, Karlsson F, et al.
Nat Commun
. 2023 Sep;
14(1):5474.
PMID: 37673883
Streptococcus pyogenes Cas9 (SpCas9) and derived enzymes are widely used as genome editors, but their promiscuous nuclease activity often induces undesired mutations and chromosomal rearrangements. Several strategies for mapping off-target...
2.
Wimberger S, Akrap N, Firth M, Brengdahl J, Engberg S, Schwinn M, et al.
Nat Commun
. 2023 Aug;
14(1):4761.
PMID: 37580318
Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of unintended mutations...
3.
Peterka M, Akrap N, Li S, Wimberger S, Hsieh P, Degtev D, et al.
Nat Commun
. 2022 Mar;
13(1):1240.
PMID: 35332138
Prime editing recently emerged as a next-generation approach for precise genome editing. Here we exploit DNA double-strand break (DSB) repair to develop two strategies that install precise genomic insertions using...
4.
Li S, Akrap N, Cerboni S, Porritt M, Wimberger S, Lundin A, et al.
Nat Commun
. 2021 May;
12(1):2832.
PMID: 33972550
No abstract available.
5.
Li S, Akrap N, Cerboni S, Porritt M, Wimberger S, Lundin A, et al.
Nat Commun
. 2021 Jan;
12(1):497.
PMID: 33479216
Prokaryotic restriction enzymes, recombinases and Cas proteins are powerful DNA engineering and genome editing tools. However, in many primary cell types, the efficiency of genome editing remains low, impeding the ...
6.
Lundin A, Porritt M, Jaiswal H, Seeliger F, Johansson C, Bidar A, et al.
Nat Commun
. 2020 Sep;
11(1):4903.
PMID: 32994412
The CRISPR-Cas9 system has increased the speed and precision of genetic editing in cells and animals. However, model generation for drug development is still expensive and time-consuming, demanding more target...
7.
Bischoff N, Wimberger S, Maresca M, Brakebusch C
Cells
. 2020 May;
9(5).
PMID: 32466303
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) genome editing has become a standard method in molecular biology, for the establishment of genetically modified cellular and animal models, for the identification...
8.
Karapetyan A, Chaipan C, Winkelbach K, Wimberger S, Jeong J, Joshi B, et al.
Front Immunol
. 2019 Nov;
10:2501.
PMID: 31695703
Adoptive T cell therapy using patient T cells redirected to recognize tumor-specific antigens by expressing genetically engineered high-affinity T-cell receptors (TCRs) has therapeutic potential for melanoma and other solid tumors....