Ester Muraglia
Overview
Explore the profile of Ester Muraglia including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
753
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0
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Recent Articles
11.
Muraglia E, Altamura S, Branca D, Cecchetti O, Ferrigno F, Vittoria Orsale M, et al.
Bioorg Med Chem Lett
. 2008 Oct;
18(23):6083-7.
PMID: 18930398
Trifluoroacetylthiophene carboxamides have recently been reported to be class II HDAC inhibitors, with moderate selectivity. Exploration of replacements for the carboxamide with bioisosteric pentatomic heteroaromatic like 1,3,4-oxadiazoles, 1,2,4-oxadiazoles and 1,3-thiazoles,...
12.
Summa V, Petrocchi A, Bonelli F, Crescenzi B, Donghi M, Ferrara M, et al.
J Med Chem
. 2008 Sep;
51(18):5843-55.
PMID: 18763751
Human immunodeficiency virus type-1 (HIV-1) integrase is one of the three virally encoded enzymes required for replication and therefore a rational target for chemotherapeutic intervention in the treatment of HIV-1...
13.
Muraglia E, Kinzel O, Gardelli C, Crescenzi B, Donghi M, Ferrara M, et al.
J Med Chem
. 2008 Jan;
51(4):861-74.
PMID: 18217703
HIV integrase is one of the three enzymes encoded by HIV genome and is essential for viral replication, but integrase inhibitors as marketed drugs have just very recently started to...
14.
Gardelli C, Nizi E, Muraglia E, Crescenzi B, Ferrara M, Orvieto F, et al.
J Med Chem
. 2007 Sep;
50(20):4953-75.
PMID: 17824681
The human immunodeficiency virus type-1 (HIV-1) encodes three enzymes essential for viral replication: a reverse transcriptase, a protease, and an integrase. The latter is responsible for the integration of the...
15.
Pace P, Di Francesco M, Gardelli C, Harper S, Muraglia E, Nizi E, et al.
J Med Chem
. 2007 Apr;
50(9):2225-39.
PMID: 17428043
Human immunodeficiency virus type-1 (HIV-1) integrase, one of the three constitutive viral enzymes required for replication, is a rational target for chemotherapeutic intervention in the treatment of AIDS that has...
16.
Bottomley M, Muraglia E, Bazzo R, Carfi A
J Biol Chem
. 2007 Mar;
282(18):13592-600.
PMID: 17363368
Many Gram-negative bacteria communicate via molecules called autoinducers to coordinate the activities of their populations. Such communication is termed quorum sensing and can regulate pathogenic virulence factor production and antimicrobial...
17.
Summa V, Petrocchi A, Matassa V, Gardelli C, Muraglia E, Rowley M, et al.
J Med Chem
. 2006 Dec;
49(23):6646-9.
PMID: 17154493
The dihydroxypyrimidine carboxamide 4a was discovered as a potent and selective HIV integrase strand transfer inhibitor. The optimization of physicochemical properties, pharmacokinetic profiles, and potency led to the identification of...
18.
Kinzel O, Fattori D, Muraglia E, Gallinari P, Nardi M, Paolini C, et al.
J Med Chem
. 2006 Sep;
49(18):5404-7.
PMID: 16942012
A strategy to obtain a fully orthogonal estrogen-receptor-based gene switch responsive to molecules with acceptable pharmacological properties is presented. From a series of tetrahydrofluorenones active on the wild-type estrogen receptor...
19.
Muraglia E, Kinzel O, Laufer R, Miller M, Moyer G, Munshi V, et al.
Bioorg Med Chem Lett
. 2006 Mar;
16(10):2748-52.
PMID: 16503141
A series of aryltetrazolylacetanilides was synthesized and evaluated as HIV-1 non-nucleoside reverse transcriptase inhibitors on wild-type virus and on the clinically relevant K103N mutant strain. Extensive SAR investigation led to...
20.
Gallinari P, Lahm A, Koch U, Paolini C, Nardi M, Roscilli G, et al.
Chem Biol
. 2005 Aug;
12(8):883-93.
PMID: 16125100
It is highly desirable to design ligand-dependent transcription regulation systems based on transactivators unresponsive to endogenous ligands but induced by synthetic small molecules unable to activate endogenous receptors. Using molecular...