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Ester Muraglia

Explore the profile of Ester Muraglia including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 26
Citations 753
Followers 0
Related Specialties
Biochemistry
Chemistry
Molecular Biology
Top 10 Co-Authors
Michael Rowley
Philip Jones
Ralph Laufer
Federica Orvieto
Edith Monteagudo
Uwe Koch
Olaf Kinzel
Danila Branca
Vincenzo Summa
Maria Cecilia Palumbi
Published In
Bioorg Med Chem Lett
J Med Chem
J Virol
Acta Crystallogr D Biol Crystallogr
EMBO Rep
Affiliations
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Recent Articles
21.
Novel, potent phenethylamide inhibitors of the hepatitis C virus (HCV) NS3 protease: probing the role of P2 aryloxyprolines with hybrid structures
Orvieto F, Koch U, Matassa V, Muraglia E
Bioorg Med Chem Lett . 2003 Jul; 13(16):2745-8. PMID: 12873506
Synthesis of hybrid HCV NS3 protease/NS4A inhibitors having the 4,4-difluoroaminobutyric acid (difluoroAbu) phenethylamides as P1-P1' and quinolyloxyprolines as P2 fragments led to 7 (IC(50) 54 nM). Molecular modelling suggests that...
22.
A novel, inducible, eukaryotic gene expression system based on the quorum-sensing transcription factor TraR
Neddermann P, Gargioli C, Muraglia E, Sambucini S, Bonelli F, De Francesco R, et al.
EMBO Rep . 2003 Mar; 4(2):159-65. PMID: 12612605
Bacteria adapt their pattern of gene expression in response to a variety of external cues, including fluctuations in population density. This type of bacterial cell-to-cell communication is referred to as...
23.
In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor
Trozzi C, Bartholomew L, Ceccacci A, Biasiol G, Pacini L, Altamura S, et al.
J Virol . 2003 Mar; 77(6):3669-79. PMID: 12610142
The hepatitis C virus (HCV) serine protease is necessary for viral replication and represents a valid target for developing new therapies for HCV infection. Potent and selective inhibitors of this...
24.
The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA
Vannini A, Volpari C, Gargioli C, Muraglia E, Cortese R, De Francesco R, et al.
EMBO J . 2002 Aug; 21(17):4393-401. PMID: 12198141
The quorum sensing system allows bacteria to sense their cell density and initiate an altered pattern of gene expression after a sufficient quorum of cells has accumulated. In Agrobacterium tumefaciens,...
25.
Crystallization and preliminary X-ray diffraction studies of the transcriptional regulator TraR bound to its cofactor and to a specific DNA sequence
Vannini A, Volpari C, Gargioli C, Muraglia E, De Francesco R, Neddermann P, et al.
Acta Crystallogr D Biol Crystallogr . 2002 Jul; 58(Pt 8):1362-4. PMID: 12136156
TraR is an Agrobacterium tumefaciens transcriptional regulator which binds the pheromone N-3-oxooctanoyl-L-homoserine lactone (AAI) in response to the bacterial population density. The TraR-AAI complex dimerizes and interacts with a specific...
26.
Evolution, synthesis and SAR of tripeptide alpha-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease
Colarusso S, Gerlach B, Koch U, Muraglia E, Conte I, Stansfield I, et al.
Bioorg Med Chem Lett . 2002 Feb; 12(4):705-8. PMID: 11844706
N-terminal truncation of the hexapeptide ketoacid 1 gave rise to potent tripeptide inhibitors of the hepatitis C virus NS3 protease/NS4A cofactor complex. Optimization of these tripeptides led to ketoacid 30...