Erkang Fan
Overview
Explore the profile of Erkang Fan including associated specialties, affiliations and a list of published articles.
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Articles
101
Citations
1822
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Recent Articles
1.
Sigalapalli D, Groustra S, Fenwick M, Zigweid R, Hulverson M, Owsley E, et al.
Bioorg Med Chem Lett
. 2025 Jan;
119:130092.
PMID: 39778753
Cryptosporidium parvum is a protozoan parasite that causes severe diarrheal illness in children and each year nearly 50,000 children under age 5 die due to the disease. Despite tremendous research...
2.
Molasky N, Zhang Z, Gillespie J, Domagala J, Reyna D, Lipka E, et al.
Antimicrob Agents Chemother
. 2024 Oct;
68(12):e0074524.
PMID: 39470194
New antibiotics are needed to treat gram-positive bacterial pathogens. is a novel inhibitor of methionyl-tRNA synthetase with selective activity against gram-positive bacteria. The minimum inhibitory concentrations (MICs) against and species...
3.
de Sousa M, Imhof D, Hanggeli K, Choi R, Hulverson M, Arnold S, et al.
Int J Parasitol Drugs Drug Resist
. 2024 Jun;
25:100553.
PMID: 38917582
Toxoplasma gondii and Neospora caninum are major worldwide morbidity-causing pathogens. Bumped kinase inhibitors (BKIs) are a compound class that has been optimized to target the apicomplexan calcium-dependent protein kinase 1...
4.
Ajiboye J, Uldry A, Heller M, Naguleswaran A, Fan E, Van Voorhis W, et al.
Int J Mol Sci
. 2024 Mar;
25(5).
PMID: 38473953
is an apicomplexan parasite causing persistent diarrhea in humans and animals. Issuing from target-based drug development, calcium-dependent protein kinase 1 inhibitors, collectively named bumped kinase inhibitors (BKIs), with excellent efficacies...
5.
Fenwick M, Reers A, Liu Y, Zigweid R, Sankaran B, Shin J, et al.
ACS Infect Dis
. 2023 Sep;
9(10):1821-1833.
PMID: 37722671
Each year, approximately 50,000 children under 5 die as a result of diarrhea caused by , a protozoan parasite. There are currently no effective drugs or vaccines available to cure...
6.
Hulverson M, Choi R, Schaefer D, Betzer D, McCloskey M, Whitman G, et al.
Antimicrob Agents Chemother
. 2023 Mar;
67(4):e0142522.
PMID: 36920244
Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and...
7.
Michaels S, Hulverson M, Whitman G, Tran L, Choi R, Fan E, et al.
Antimicrob Agents Chemother
. 2022 Jun;
66(7):e0001722.
PMID: 35703552
A phenotypic screen of the ReFRAME compound library was performed to identify cell-active inhibitors that could be developed as therapeutics for giardiasis. A primary screen against Giardia lamblia GS clone...
8.
Hasan M, Stebbins E, Choy R, Gillespie J, de Hostos E, Miller P, et al.
Antimicrob Agents Chemother
. 2021 Mar;
65(6).
PMID: 33753338
The intestinal protozoan is a leading cause of diarrheal disease and mortality in young children. There is currently no fully effective treatment for cryptosporidiosis, which has stimulated interest in anticryptosporidial...
9.
Zhang Z, Barros-Alvarez X, Gillespie J, Ranade R, Huang W, Shibata S, et al.
RSC Med Chem
. 2021 Jan;
11(8):885-895.
PMID: 33479683
Based on crystal structures of methionyl-tRNA synthetase (MetRS) bound to inhibitors, we designed, synthesized, and evaluated two series of novel MetRS inhibitors targeting this parasite enzyme. One series has a...
10.
Van Voorhis W, Hulverson M, Choi R, Huang W, Arnold S, Schaefer D, et al.
Vet Parasitol
. 2021 Jan;
289:109336.
PMID: 33418437
This is a review of the development of bumped-kinase inhibitors (BKIs) for the therapy of One Health parasitic apicomplexan diseases. Many apicomplexan infections are shared between humans and livestock, such...