Frederick S Buckner
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Explore the profile of Frederick S Buckner including associated specialties, affiliations and a list of published articles.
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112
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2435
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Recent Articles
1.
Molasky N, Zhang Z, Gillespie J, Domagala J, Reyna D, Lipka E, et al.
Antimicrob Agents Chemother
. 2024 Oct;
68(12):e0074524.
PMID: 39470194
New antibiotics are needed to treat gram-positive bacterial pathogens. is a novel inhibitor of methionyl-tRNA synthetase with selective activity against gram-positive bacteria. The minimum inhibitory concentrations (MICs) against and species...
2.
Truong T, Crawford K, Wang-McGuire I, Jensen K, Mushtaq A, Lieberman N, et al.
Microbiol Spectr
. 2024 Sep;
12(10):e0105524.
PMID: 39248481
Importance: Leishmaniasis is a disfiguring, neglected parasitic infection endemic to the Southern United States and the Americas. Despite significant populations at risk-travelers, military and foreign service members, and migrating persons-the...
3.
Joseph S, Whitman T, Buckner F, Cogen A
Am J Trop Med Hyg
. 2021 May;
105(1):142-143.
PMID: 33970891
Cutaneous leishmaniasis (CL) is often caused by Leishmania braziliensis (L. braziliensis) in South America. Because of the risk for mucocutaneous leishmaniasis, L. braziliensis is frequently treated with parenteral or oral...
4.
Gelb M, Buckner F
ACS Infect Dis
. 2021 Apr;
7(7):1874-1876.
PMID: 33871981
In this Viewpoint, we provide a brief description of two efforts to develop drugs to treat diseases caused by tropical parasites (Malaria, human African trypanosomiasis and Chagas disease). These efforts...
5.
Hasan M, Stebbins E, Choy R, Gillespie J, de Hostos E, Miller P, et al.
Antimicrob Agents Chemother
. 2021 Mar;
65(6).
PMID: 33753338
The intestinal protozoan is a leading cause of diarrheal disease and mortality in young children. There is currently no fully effective treatment for cryptosporidiosis, which has stimulated interest in anticryptosporidial...
6.
7.
Zhang Z, Barros-Alvarez X, Gillespie J, Ranade R, Huang W, Shibata S, et al.
RSC Med Chem
. 2021 Jan;
11(8):885-895.
PMID: 33479683
Based on crystal structures of methionyl-tRNA synthetase (MetRS) bound to inhibitors, we designed, synthesized, and evaluated two series of novel MetRS inhibitors targeting this parasite enzyme. One series has a...
8.
Silva D, Junker A, de Melo S, Fumagalli F, Gillespie J, Molasky N, et al.
ChemMedChem
. 2020 Oct;
16(6):966-975.
PMID: 33078573
Neglected tropical diseases remain among the most critical public health concerns in Africa and South America. The drug treatments for these diseases are limited, which invariably leads to fatal cases....
9.
Buckner F, McCulloch D, Atluri V, Blain M, McGuffin S, Nalla A, et al.
Clin Infect Dis
. 2020 May;
71(16):2167-2173.
PMID: 32444880
Background: Washington State served as the initial epicenter of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in the United States. An understanding of the risk factors and clinical...
10.
Buckner F, Buchynskyy A, Nagendar P, Patrick D, Gillespie J, Herbst Z, et al.
Trop Med Infect Dis
. 2020 Feb;
5(1).
PMID: 32033395
The work began with the screening of a library of 700,000 small molecules for inhibitors of growth (a phenotypic screen). The resulting set of 1035 hit compounds was reviewed by...