Erin K Willert
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Explore the profile of Erin K Willert including associated specialties, affiliations and a list of published articles.
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9
Citations
199
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Recent Articles
1.
Willert E, Kinch L, Phillips M
Methods Mol Biol
. 2011 Feb;
720:219-35.
PMID: 21318877
Polyamine biosynthesis is extensively regulated in cells by multiple mechanisms, including regulation of enzyme activity posttranslationally. The identified regulatory factors include both small molecules and regulatory proteins, and the mechanisms...
2.
Goodwin M, Molleston J, Canny S, Abou El Hassan M, Willert E, Bremner R, et al.
J Virol
. 2010 Aug;
84(22):12039-47.
PMID: 20719946
Gammaherpesviruses are important oncogenic pathogens that transit between lytic and latent life cycles. Silencing the lytic gene expression program enables the establishment of latency and a lifelong chronic infection of...
3.
Johnson L, Willert E, Virgin H
Cell Host Microbe
. 2010 Jun;
7(6):516-26.
PMID: 20542255
Viral genetic studies typically focus on large open reading frames (ORFs) identified during genome annotation (ORF-based annotation). Here we describe tools for examining viral gene expression nucleotide by nucleotide across...
4.
Willert E, Phillips M
Mol Biochem Parasitol
. 2009 Jun;
168(1):1-6.
PMID: 19523496
The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas disease (American trypanosomiasis), a neglected disease of Central and South America. Polyamines are small organic cations that are required...
5.
Hirth B, Barker Jr R, Celatka C, Klinger J, Liu H, Nare B, et al.
Bioorg Med Chem Lett
. 2009 May;
19(11):2916-9.
PMID: 19419862
Modification of the structure of trypanosomal AdoMetDC inhibitor 1 (MDL73811) resulted in the identification of a new inhibitor 7a, which features a methyl substituent at the 8-position. Compound 7a exhibits...
6.
Barker Jr R, Liu H, Hirth B, Celatka C, Fitzpatrick R, Xiang Y, et al.
Antimicrob Agents Chemother
. 2009 Mar;
53(5):2052-8.
PMID: 19289530
Trypanosomiasis remains a significant disease across the sub-Saharan African continent, with 50,000 to 70,000 individuals infected. The utility of current therapies is limited by issues of toxicity and the need...
7.
Willert E, Phillips M
PLoS Pathog
. 2008 Oct;
4(10):e1000183.
PMID: 18949025
Trypanosoma brucei is the causative agent of African sleeping sickness. The polyamine biosynthetic pathway has the distinction of being the target of the only clinically proven anti-trypanosomal drug with a...
8.
Willert E, Fitzpatrick R, Phillips M
Proc Natl Acad Sci U S A
. 2007 May;
104(20):8275-80.
PMID: 17485680
African sleeping sickness is a fatal disease that is caused by the protozoan parasite Trypanosoma brucei. Polyamine biosynthesis is an essential pathway in the parasite and is a validated drug...
9.
Beswick T, Willert E, Phillips M
Biochemistry
. 2006 Jun;
45(25):7797-807.
PMID: 16784231
S-Adenosylmethionine decarboxylase (AdoMetDC) is a pyruvoyl-dependent enzyme that catalyzes an essential step in polyamine biosynthesis. The polyamines are required for cell growth, and the biosynthetic enzymes are targets for antiproliferative...