Cassandra A Celatka
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Explore the profile of Cassandra A Celatka including associated specialties, affiliations and a list of published articles.
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10
Citations
124
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Recent Articles
1.
Jasmine S, Mandl A, Krueger T, Dalrymple S, Antony L, Dias J, et al.
Prostate
. 2024 Apr;
84(10):909-921.
PMID: 38619005
Introduction: Lysine-specific demethylase 1 (LSD1) is emerging as a critical mediator of tumor progression in metastatic castration-resistant prostate cancer (mCRPC). Neuroendocrine prostate cancer (NEPC) is increasingly recognized as an adaptive...
2.
Padalino G, Celatka C, Rienhoff Jr H, Kalin J, Cole P, Lassalle D, et al.
Wellcome Open Res
. 2023 Jul;
8:146.
PMID: 37520936
: , a parasitic worm species responsible for the neglected tropical disease schistosomiasis, undergoes strict developmental regulation of gene expression that is carefully controlled by both genetic and epigenetic processes....
3.
Skerlj R, Bastos C, Booker M, Kramer M, Barker Jr R, Celatka C, et al.
ACS Med Chem Lett
. 2014 Jun;
2(9):708-13.
PMID: 24900364
Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum...
4.
Martyn D, Nijjar A, Celatka C, Mazitschek R, Cortese J, Tyndall E, et al.
Bioorg Med Chem Lett
. 2009 Nov;
20(1):228-31.
PMID: 19914064
Two sets of diaminopyrimidines, totalling 45 compounds, were synthesized and assayed against Plasmodium falciparum. The SAR was relatively shallow, with only the presence of a 2-(pyrrolidin-1-yl)ethyl group at R(2) significantly...
5.
Hirth B, Barker Jr R, Celatka C, Klinger J, Liu H, Nare B, et al.
Bioorg Med Chem Lett
. 2009 May;
19(11):2916-9.
PMID: 19419862
Modification of the structure of trypanosomal AdoMetDC inhibitor 1 (MDL73811) resulted in the identification of a new inhibitor 7a, which features a methyl substituent at the 8-position. Compound 7a exhibits...
6.
Barker Jr R, Liu H, Hirth B, Celatka C, Fitzpatrick R, Xiang Y, et al.
Antimicrob Agents Chemother
. 2009 Mar;
53(5):2052-8.
PMID: 19289530
Trypanosomiasis remains a significant disease across the sub-Saharan African continent, with 50,000 to 70,000 individuals infected. The utility of current therapies is limited by issues of toxicity and the need...
7.
Patel V, Booker M, Kramer M, Ross L, Celatka C, Kennedy L, et al.
J Biol Chem
. 2008 Oct;
283(50):35078-85.
PMID: 18842591
Plasmodium falciparum causes the most deadly form of malaria and accounts for over one million deaths annually. The malaria parasite is unable to salvage pyrimidines and relies on de novo...
8.
Lin J, Deng H, Jin L, Pandey P, Quinn J, Cantin S, et al.
J Med Chem
. 2006 Dec;
49(26):7781-91.
PMID: 17181160
Human coagulation factor XIa (FXIa), a serine protease activated by site-specific cleavage of factor XI by thrombin, FXIIa, or autoactivation, is a critical enzyme in the amplification phase of the...
9.
Deng H, Bannister T, Jin L, Babine R, Quinn J, Nagafuji P, et al.
Bioorg Med Chem Lett
. 2006 Mar;
16(11):3049-54.
PMID: 16524727
Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in...
10.
Panek J, Beresis R, Celatka C
J Org Chem
. 1996 Sep;
61(19):6494-6495.
PMID: 11667509
No abstract available.