Erik van Nimwegen
Overview
Explore the profile of Erik van Nimwegen including associated specialties, affiliations and a list of published articles.
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89
Citations
6888
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Recent Articles
1.
Grobecker P, Sakoparnig T, van Nimwegen E
PLoS Comput Biol
. 2024 Jul;
20(7):e1012224.
PMID: 38995959
Single-cell RNA sequencing (scRNA-seq) has become a popular experimental method to study variation of gene expression within a population of cells. However, obtaining an accurate picture of the diversity of...
2.
Bak M, van Nimwegen E, Kouzel I, Gur T, Schmidt R, Zavolan M, et al.
Nat Commun
. 2024 May;
15(1):4110.
PMID: 38750024
Maturation of eukaryotic pre-mRNAs via splicing and polyadenylation is modulated across cell types and conditions by a variety of RNA-binding proteins (RBPs). Although there exist over 1,500 RBPs in human...
3.
Sollier J, Basler M, Broz P, Dittrich P, Drescher K, Egli A, et al.
Nat Microbiol
. 2024 Jan;
9(1):1-3.
PMID: 38177300
No abstract available.
4.
Katsantoni M, van Nimwegen E, Zavolan M
Genome Biol
. 2023 Apr;
24(1):77.
PMID: 37069586
We present RCRUNCH, an end-to-end solution to CLIP data analysis for identification of binding sites and sequence specificity of RNA-binding proteins. RCRUNCH can analyze not only reads that map uniquely...
5.
de Groot D, Tjalma A, Bruggeman F, van Nimwegen E
Proc Natl Acad Sci U S A
. 2023 Feb;
120(8):e2211091120.
PMID: 36780518
Microbes in the wild face highly variable and unpredictable environments and are naturally selected for their average growth rate across environments. Apart from using sensory regulatory systems to adapt in...
6.
Mukhtar T, Breda J, Adam M, Boareto M, Grobecker P, Karimaddini Z, et al.
EMBO J
. 2022 Nov;
41(24):e111132.
PMID: 36345783
The cerebral cortex contains billions of neurons, and their disorganization or misspecification leads to neurodevelopmental disorders. Understanding how the plethora of projection neuron subtypes are generated by cortical neural stem...
7.
Baranasic D, Hortenhuber M, Balwierz P, Zehnder T, Mukarram A, Nepal C, et al.
Nat Genet
. 2022 Jul;
54(7):1037-1050.
PMID: 35789323
Zebrafish, a popular organism for studying embryonic development and for modeling human diseases, has so far lacked a systematic functional annotation program akin to those in other animal models. To...
8.
Urchueguia A, Galbusera L, Chauvin D, Bellement G, Julou T, van Nimwegen E
PLoS Biol
. 2021 Dec;
19(12):e3001491.
PMID: 34919538
Although it is well appreciated that gene expression is inherently noisy and that transcriptional noise is encoded in a promoter's sequence, little is known about the extent to which noise...
9.
Bloom J, Chan Y, Baric R, Bjorkman P, Cobey S, Deverman B, et al.
Science
. 2021 May;
372(6543):694.
PMID: 33986172
No abstract available.
10.
Breda J, Zavolan M, van Nimwegen E
Nat Biotechnol
. 2021 Apr;
39(8):1008-1016.
PMID: 33927416
Despite substantial progress in single-cell RNA-seq (scRNA-seq) data analysis methods, there is still little agreement on how to best normalize such data. Starting from the basic requirements that inferred expression...